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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4654
Target Type SINGLE PROTEIN
Preferred Name Histamine H2 receptor
Synonyms Gastric receptor I | H2R | HH2R | Histamine H2 receptor | Hrh2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > histamine receptor

Target Components

Component Description Relationship Accession
Histamine H2 receptor SINGLE PROTEIN P25102

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004969 (histamine receptor activity)
GO:1901363 (heterocyclic compound binding)
GO Biological Process GO:0001696 (gastric acid secretion)
GO:0001697 (histamine-induced gastric acid secretion)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0045907 (positive regulation of vasoconstriction)
GO:0071420 (cellular response to histamine)
GO:1900139 (negative regulation of arachidonic acid secretion)

Target Cross References - Protein

canSAR P25102
IntAct P25102
Guide to Pharmacology 263
UniProt P25102

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000503 (Histamine_H2_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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