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Target Report Card

Target Name and Classification

Target ID CHEMBL4648
Preferred Name Diamine oxidase
Synonyms Abp1 | Amiloride-binding protein 1 | Amiloride-sensitive amine oxidase [copper-containing] | Amine oxidase copper domain-containing protein 1 | Aoc1 | DAO | Diamine oxidase | Histaminase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Amiloride-sensitive amine oxidase [copper-containing] SINGLE PROTEIN P36633

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0005923 (bicellular tight junction)
GO Molecular Function GO:0005507 (copper ion binding)
GO:0008131 (primary amine oxidase activity)
GO:0008144 (drug binding)
GO:0008201 (heparin binding)
GO:0008270 (zinc ion binding)
GO:0016491 (oxidoreductase activity)
GO:0038023 (signaling receptor activity)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO:0048038 (quinone binding)
GO:0052597 (diamine oxidase activity)
GO:0052598 (histamine oxidase activity)
GO:0052599 (methylputrescine oxidase activity)
GO:0052600 (propane-1,3-diamine oxidase activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0008150 (biological_process)
GO:0009308 (amine metabolic process)
GO:0035874 (cellular response to copper ion starvation)
GO:0042493 (response to drug)
GO:0046677 (response to antibiotic)
GO:0055114 (oxidation-reduction process)
GO:0071280 (cellular response to copper ion)
GO:0071420 (cellular response to histamine)
GO:0097185 (cellular response to azide)

Target Cross References - Protein

canSAR P36633
UniProt P36633 Q63973

Target Cross References - Domain

InterPro IPR000269 (Cu_amine_oxidase.)
IPR015798 (Cu_amine_oxidase_C.)
IPR015800 (Cu_amine_oxidase_N2.)
IPR015802 (Cu_amine_oxidase_N3.)
IPR016182 (Cu_amine_oxidase_N-reg.)
IPR036460 (Cu_amine_oxidase_C_sf.)
Pfam PF01179 (Cu_amine_oxid)
PF02727 (Cu_amine_oxidN2)
PF02728 (Cu_amine_oxidN3)