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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL4642
Target Type SINGLE PROTEIN
Preferred Name Serotonin transporter
Synonyms 5HT transporter | 5HTT | Htt | SERT | Sert | Slc6a4 | Sodium-dependent serotonin transporter | Solute carrier family 6 member 4
Organism Mus musculus
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc06 neurotransmitter transporter family

Target Components

Component Description Relationship Accession
Sodium-dependent serotonin transporter SINGLE PROTEIN Q60857

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0010008 (endosome membrane)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO:0045121 (membrane raft)
GO:0098793 (presynapse)
GO Molecular Function GO:0005328 (neurotransmitter:sodium symporter activity)
GO:0005330 (dopamine:sodium symporter activity)
GO:0005335 (serotonin:sodium symporter activity)
GO:0005515 (protein binding)
GO:0008504 (monoamine transmembrane transporter activity)
GO:0015222 (serotonin transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0017022 (myosin binding)
GO:0017075 (syntaxin-1 binding)
GO:0017137 (Rab GTPase binding)
GO:0019811 (cocaine binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0050998 (nitric-oxide synthase binding)
GO:0051015 (actin filament binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006836 (neurotransmitter transport)
GO:0006837 (serotonin transport)
GO:0007420 (brain development)
GO:0007584 (response to nutrient)
GO:0007613 (memory)
GO:0007623 (circadian rhythm)
GO:0009636 (response to toxic substance)
GO:0010033 (response to organic substance)
GO:0010628 (positive regulation of gene expression)
GO:0014064 (positive regulation of serotonin secretion)
GO:0015844 (monoamine transport)
GO:0021941 (negative regulation of cerebellar granule cell precursor proliferation)
GO:0032227 (negative regulation of synaptic transmission, dopaminergic)
GO:0032355 (response to estradiol)
GO:0035176 (social behavior)
GO:0042310 (vasoconstriction)
GO:0042493 (response to drug)
GO:0042713 (sperm ejaculation)
GO:0045665 (negative regulation of neuron differentiation)
GO:0045787 (positive regulation of cell cycle)
GO:0046621 (negative regulation of organ growth)
GO:0048854 (brain morphogenesis)
GO:0051259 (protein oligomerization)
GO:0051260 (protein homooligomerization)
GO:0051583 (dopamine uptake involved in synaptic transmission)
GO:0051610 (serotonin uptake)
GO:0055085 (transmembrane transport)
GO:0071300 (cellular response to retinoic acid)
GO:0071310 (cellular response to organic substance)
GO:0071321 (cellular response to cGMP)
GO:0090067 (regulation of thalamus size)

Target Cross References - Protein

IntAct Q60857
MICAD NBK23133 (Serotonin transporter (SERT))
NBK23143 (Serotonin transporter (SERT))
NBK23163 (Serotonin transporter)
NBK23221 (Serotonin transporter (SERT))
NBK23298 (Serotonin transporter (SERT); 5-HT)
NBK23385 (Serotonin transporter)
NBK23486 (Serotonin transporter (SERT))
NBK23655 (Serotonin transporter)
NBK23720 (Serotonin transporter (SERT))
NBK53695 (Serotonin transporter (SERT))
NBK53698 (Serotonin transporter (SERT))
Reactome R-MMU-380615 (Serotonin clearance from the synaptic cleft.)
UniProt O35241 Q5NCR6 Q60857

Target Cross References - Domain

InterPro IPR000175 (Na/ntran_symport.)
IPR013086 (Na/ntran_symport_serotonin_N.)
IPR037272 (SNS_sf.)
Pfam PF00209 (SNF)
PF03491 (5HT_transport_N)
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