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Target Report Card

Target Name and Classification

Target ID CHEMBL4637
Target Type SINGLE PROTEIN
Preferred Name AMP-activated protein kinase, alpha-2 subunit
Synonyms 5'-AMP-activated protein kinase catalytic subunit alpha-2 | ACACA kinase | AMPK subunit alpha-2 | Acetyl-CoA carboxylase kinase | Ampk | Ampk2 | HMGCR kinase | Hydroxymethylglutaryl-CoA reductase kinase | Prkaa2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase ampk subfamily

Target Components

Component Description Relationship Accession
5'-AMP-activated protein kinase catalytic subunit alpha-2 SINGLE PROTEIN Q09137

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0016324 (apical plasma membrane)
GO:0031588 (nucleotide-activated protein kinase complex)
GO:0043234 (protein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003682 (chromatin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004679 (AMP-activated protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030674 (protein binding, bridging)
GO:0035174 (histone serine kinase activity)
GO:0046872 (metal ion binding)
GO:0047322 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity)
GO:0050405 ([acetyl-CoA carboxylase] kinase activity)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006694 (steroid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0006914 (autophagy)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0008610 (lipid biosynthetic process)
GO:0010508 (positive regulation of autophagy)
GO:0014823 (response to activity)
GO:0016055 (Wnt signaling pathway)
GO:0016126 (sterol biosynthetic process)
GO:0016241 (regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0016568 (chromatin modification)
GO:0019216 (regulation of lipid metabolic process)
GO:0031000 (response to caffeine)
GO:0031669 (cellular response to nutrient levels)
GO:0032007 (negative regulation of TOR signaling)
GO:0035404 (histone-serine phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0042149 (cellular response to glucose starvation)
GO:0042304 (regulation of fatty acid biosynthetic process)
GO:0042593 (glucose homeostasis)
GO:0042752 (regulation of circadian rhythm)
GO:0043066 (negative regulation of apoptotic process)
GO:0045821 (positive regulation of glycolytic process)
GO:0048511 (rhythmic process)
GO:0051291 (protein heterooligomerization)
GO:0055089 (fatty acid homeostasis)
GO:0071417 (cellular response to organonitrogen compound)
GO:2000505 (regulation of energy homeostasis)

Target Cross References - Protein

canSAR Q09137
IntAct Q09137
Reactome R-RNO-163680 (AMPK inhibits chREBP transcriptional activation activity.)
UniProt Q09137

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028375 (KA1/Ssp2_C.)
IPR032270 (AMPK_C.)
Pfam PF00069 (Pkinase)
PF16579 (AdenylateSensor)
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