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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4632
Target Type SINGLE PROTEIN
Preferred Name Palmitoyl-CoA oxidase
Synonyms AOX | Acox | Acox1 | Palmitoyl-CoA oxidase | Peroxisomal acyl-CoA oxidase 1, A chain | Peroxisomal acyl-CoA oxidase 1, B chain | Peroxisomal acyl-CoA oxidase 1, C chain | Peroxisomal acyl-coenzyme A oxidase 1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Peroxisomal acyl-coenzyme A oxidase 1 SINGLE PROTEIN P07872

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005777 (peroxisome)
GO Molecular Function GO:0000062 (fatty-acyl-CoA binding)
GO:0003995 (acyl-CoA dehydrogenase activity)
GO:0003997 (acyl-CoA oxidase activity)
GO:0005504 (fatty acid binding)
GO:0009055 (electron carrier activity)
GO:0016401 (palmitoyl-CoA oxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0052890 (oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor)
GO Biological Process GO:0006091 (generation of precursor metabolites and energy)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006635 (fatty acid beta-oxidation)
GO:0006693 (prostaglandin metabolic process)
GO:0008152 (metabolic process)
GO:0019395 (fatty acid oxidation)
GO:0033539 (fatty acid beta-oxidation using acyl-CoA dehydrogenase)
GO:0033540 (fatty acid beta-oxidation using acyl-CoA oxidase)
GO:0055088 (lipid homeostasis)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P07872
IntAct P07872
UniProt P07872 P11354

Target Cross References - Domain

InterPro IPR002655 (Acyl-CoA_oxidase_C.)
IPR006091 (Acyl-CoA_Oxase/DH_cen-dom.)
IPR009075 (AcylCo_DH/oxidase_C.)
IPR009100 (AcylCoA_DH/oxidase_NM_dom.)
IPR012258 (Acyl-CoA_oxidase.)
IPR013786 (AcylCoA_DH/ox_N.)
IPR029320 (Acyl-CoA_ox_N.)
IPR034171 (ACO.)
Pfam PF01756 (ACOX)
PF02770 (Acyl-CoA_dh_M)
PF14749 (Acyl-CoA_ox_N)

Target Cross References - Structure

PDBe 1IS2 2DDH
CREDO 1IS2 2DDH
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