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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4619
Preferred Name Phosphodiesterase 1C
Synonyms Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Cam-PDE 1C | PDE1C | hCam-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 1 > phosphodiesterase 1c

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C SINGLE PROTEIN Q14123

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363066 3',5'-cyclic phosphodiesterase PROTEIN FAMILY
CHEMBL2097161 Phosphodiesterase, PDE1/PDE5 PROTEIN FAMILY
CHEMBL2095150 Phosphodiesterase 1 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000154678
Ensembl ENSG00000154678
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0004117 (calmodulin-dependent cyclic-nucleotide phosphodiesterase activity)
GO:0005516 (calmodulin binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0007165 (signal transduction)
Wikipedia PDE1C

Target Cross References - Protein

canSAR Q14123
Human Protein Atlas ENSG00000154678
Guide to Pharmacology 1296
Open Targets ENSG00000154678
PharmGKB PA33124
Reactome R-HSA-111957 (Cam-PDE 1 activation.)
UniProt B3KPC6 E9PE92 Q14123 Q14124 Q8NB10

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003607 (HD/PDEase_dom.)
IPR013706 (PDEase_N.)
IPR023088 (PDEase.)
IPR023174 (PDEase_CS.)
IPR036971 (PDEase_catalytic_dom_sf.)
Pfam PF00233 (PDEase_I)
PF08499 (PDEase_I_N)