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Target Report Card

Target Name and Classification

Target ID CHEMBL4607
Target Type SINGLE PROTEIN
Preferred Name Angiotensin II type 2 (AT-2) receptor
Synonyms AGTR2 | AT2 | Angiotensin II type-2 receptor | Type-2 angiotensin II receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > angiotensin receptor

Target Components

Component Description Relationship Accession
Type-2 angiotensin II receptor SINGLE PROTEIN P50052

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094256 Angiotensin II receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180772
Ensembl ENSG00000180772
GO Cellular Component GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004945 (angiotensin type II receptor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0017046 (peptide hormone binding)
GO:0048019 (receptor antagonist activity)
GO Biological Process GO:0001822 (kidney development)
GO:0001974 (blood vessel remodeling)
GO:0001991 (regulation of systemic arterial blood pressure by circulatory renin-angiotensin)
GO:0002018 (renin-angiotensin regulation of aldosterone production)
GO:0002033 (vasodilation by angiotensin involved in regulation of systemic arterial blood pressure)
GO:0002035 (brain renin-angiotensin system)
GO:0006883 (cellular sodium ion homeostasis)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007199 (G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)
GO:0007263 (nitric oxide mediated signal transduction)
GO:0007420 (brain development)
GO:0008217 (regulation of blood pressure)
GO:0008284 (positive regulation of cell proliferation)
GO:0010243 (response to organonitrogen compound)
GO:0010459 (negative regulation of heart rate)
GO:0010700 (negative regulation of norepinephrine secretion)
GO:0021695 (cerebellar cortex development)
GO:0030308 (negative regulation of cell growth)
GO:0032304 (negative regulation of icosanoid secretion)
GO:0032516 (positive regulation of phosphoprotein phosphatase activity)
GO:0035556 (intracellular signal transduction)
GO:0035566 (regulation of metanephros size)
GO:0035640 (exploration behavior)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0035932 (aldosterone secretion)
GO:0038166 (angiotensin-activated signaling pathway)
GO:0042312 (regulation of vasodilation)
GO:0042416 (dopamine biosynthetic process)
GO:0042981 (regulation of apoptotic process)
GO:0042990 (regulation of transcription factor import into nucleus)
GO:0043537 (negative regulation of blood vessel endothelial cell migration)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045909 (positive regulation of vasodilation)
GO:0048147 (negative regulation of fibroblast proliferation)
GO:0050715 (positive regulation of cytokine secretion)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051387 (negative regulation of neurotrophin TRK receptor signaling pathway)
GO:0060993 (kidney morphogenesis)
GO:0061049 (cell growth involved in cardiac muscle cell development)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0072300 (positive regulation of metanephric glomerulus development)
GO:0090190 (positive regulation of branching involved in ureteric bud morphogenesis)
GO:1900116 (extracellular negative regulation of signal transduction)
GO:2001238 (positive regulation of extrinsic apoptotic signaling pathway)
Wikipedia Angiotensin_II_receptor_type_2

Target Cross References - Protein

canSAR P50052
CGD Mental retardation, X-linked 88
Human Protein Atlas ENSG00000180772
IntAct P50052
Guide to Pharmacology 35
Open Targets ENSG00000180772
PharmGKB PA44
Pharos P50052 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt B2R9V1 P50052 Q13016 Q6FGY7

Target Cross References - Domain

InterPro IPR000147 (ATII_AT2_rcpt.)
IPR000248 (ATII_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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