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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4601
Preferred Name Tyrosine-protein kinase BRK
Synonyms BRK | Breast tumor kinase | PTK6 | Protein-tyrosine kinase 6 | Tyrosine-protein kinase BRK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Protein-tyrosine kinase 6 SINGLE PROTEIN Q13882

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL24828 VANDETANIB Tyrosine-protein kinase BRK inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101213
Ensembl ENSG00000101213
GO Cellular Component GO:0001726 (ruffle)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016604 (nuclear body)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007260 (tyrosine phosphorylation of STAT protein)
GO:0009968 (negative regulation of signal transduction)
GO:0010976 (positive regulation of neuron projection development)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038128 (ERBB2 signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0045087 (innate immune response)
GO:0045742 (positive regulation of epidermal growth factor receptor signaling pathway)
GO:0045787 (positive regulation of cell cycle)
GO:0045926 (negative regulation of growth)
GO:0046777 (protein autophosphorylation)
GO:0060575 (intestinal epithelial cell differentiation)
GO:0061099 (negative regulation of protein tyrosine kinase activity)
GO:0071300 (cellular response to retinoic acid)
Wikipedia PTK6

Target Cross References - Protein

canSAR Q13882
Human Protein Atlas ENSG00000101213
IntAct Q13882
Guide to Pharmacology 2182
Open Targets ENSG00000101213
PharmGKB PA33960
Pharos Q13882 (Tchem)
Reactome R-HSA-187577 (SCF(Skp2)-mediated degradation of p27/p21.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-8847993 (ERBB2 Activates PTK6 Signaling.)
R-HSA-8849468 (PTK6 Regulates Proteins Involved in RNA Processing.)
R-HSA-8849469 (PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.)
R-HSA-8849470 (PTK6 Regulates Cell Cycle.)
R-HSA-8849471 (PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.)
R-HSA-8849472 (PTK6 Down-Regulation.)
R-HSA-8849473 (PTK6 Expression.)
R-HSA-8849474 (PTK6 Activates STAT3.)
R-HSA-8857538 (PTK6 promotes HIF1A stabilization.)
UniProt B2RCR3 B4DW46 Q13882 Q58F01

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR035846 (PTK6_SH2.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 5D7V 5DA3 5H2U