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Target Report Card

Target Name and Classification

Target ID CHEMBL4600
Preferred Name Serine/threonine-protein kinase PAK 1
Synonyms Alpha-PAK | PAK-1 | PAK1 | Serine/threonine-protein kinase PAK 1 | p21-activated kinase 1 | p65-PAK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase paka subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 1 SINGLE PROTEIN Q13153

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885637 Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 PROTEIN FAMILY
CHEMBL3885636 Serine/threonine-protein kinase PAK 1/PAK 2 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149269
Ensembl ENSG00000149269
GO Cellular Component GO:0001726 (ruffle)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005925 (focal adhesion)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0030018 (Z disc)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031941 (filamentous actin)
GO:0031965 (nuclear membrane)
GO:0032587 (ruffle membrane)
GO:0032991 (macromolecular complex)
GO:0042995 (cell projection)
GO:0071437 (invadopodium)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0042802 (identical protein binding)
GO:0048365 (Rac GTPase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0001666 (response to hypoxia)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006887 (exocytosis)
GO:0006915 (apoptotic process)
GO:0007266 (Rho protein signal transduction)
GO:0007346 (regulation of mitotic cell cycle)
GO:0008152 (metabolic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0010033 (response to organic substance)
GO:0010763 (positive regulation of fibroblast migration)
GO:0016310 (phosphorylation)
GO:0021549 (cerebellum development)
GO:0030010 (establishment of cell polarity)
GO:0030335 (positive regulation of cell migration)
GO:0031116 (positive regulation of microtubule polymerization)
GO:0031295 (T cell costimulation)
GO:0031532 (actin cytoskeleton reorganization)
GO:0032147 (activation of protein kinase activity)
GO:0032869 (cellular response to insulin stimulus)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0033148 (positive regulation of intracellular estrogen receptor signaling pathway)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042060 (wound healing)
GO:0042981 (regulation of apoptotic process)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0045773 (positive regulation of axon extension)
GO:0046777 (protein autophosphorylation)
GO:0048012 (hepatocyte growth factor receptor signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0048812 (neuron projection morphogenesis)
GO:0050770 (regulation of axonogenesis)
GO:0050852 (T cell receptor signaling pathway)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0060244 (negative regulation of cell proliferation involved in contact inhibition)
GO:0061052 (negative regulation of cell growth involved in cardiac muscle cell development)
GO:0090314 (positive regulation of protein targeting to membrane)
GO:1904707 (positive regulation of vascular smooth muscle cell proliferation)
GO:1904754 (positive regulation of vascular associated smooth muscle cell migration)
GO:2001275 (positive regulation of glucose import in response to insulin stimulus)
Wikipedia PAK1

Target Cross References - Protein

canSAR Q13153
Human Protein Atlas ENSG00000149269
IntAct Q13153
Guide to Pharmacology 2133
Open Targets ENSG00000149269
PharmGKB PA32917
Pharos Q13153 (Tchem)
Reactome R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-376172 (DSCAM interactions.)
R-HSA-389359 (CD28 dependent Vav1 pathway.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-428540 (Activation of RAC1.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-445355 (Smooth Muscle Contraction.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5625740 (RHO GTPases activate PKNs.)
R-HSA-5627117 (RHO GTPases Activate ROCKs.)
R-HSA-5627123 (RHO GTPases activate PAKs.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
UniProt O75561 Q13153 Q13567 Q32M53 Q32M54 Q86W79

Target Cross References - Domain

InterPro IPR000095 (CRIB_dom.)
IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR033923 (PAK_BD.)
IPR036936 (CRIB_dom_sf.)
Pfam PF00069 (Pkinase)
PF00786 (PBD)

Target Cross References - Structure

PDBe 1F3M 1YHV 1YHW 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY More...
CREDO 1F3M 1YHV 1YHW 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY More...