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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4599
Target Type SINGLE PROTEIN
Preferred Name Tyrosine kinase non-receptor protein 2
Synonyms ACK-1 | ACK1 | Activated CDC42 kinase 1 | TNK2 | Tyrosine kinase non-receptor protein 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase ack family

Target Components

Component Description Relationship Accession
Activated CDC42 kinase 1 SINGLE PROTEIN Q07912

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000061938
Ensembl ENSG00000061938
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005905 (clathrin-coated pit)
GO:0005912 (adherens junction)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0030136 (clathrin-coated vesicle)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0070436 (Grb2-EGFR complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005095 (GTPase inhibitor activity)
GO:0005154 (epidermal growth factor receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0050699 (WW domain binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006897 (endocytosis)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007264 (small GTPase mediated signal transduction)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0030154 (cell differentiation)
GO:0034260 (negative regulation of GTPase activity)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0045087 (innate immune response)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:2000369 (regulation of clathrin-mediated endocytosis)
Wikipedia TNK2

Target Cross References - Protein

canSAR Q07912
Human Protein Atlas ENSG00000061938
IntAct Q07912
Guide to Pharmacology 2246
Open Targets ENSG00000061938
PharmGKB PA134909759
Pharos Q07912 (Tchem)
UniProt Q07912 Q6ZMQ0 Q8N6U7 Q96H59

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015116 (Cdc42_binding_dom-like.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR021619 (Mig-6.)
Pfam PF07714 (Pkinase_Tyr)
PF09027 (GTPase_binding)
PF11555 (Inhibitor_Mig-6)
PF14604 (SH3_9)

Target Cross References - Structure

PDBe 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7
CREDO 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7
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