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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4597
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase PCTAIRE-1
Synonyms CDK16 | Cell division protein kinase 16 | Cyclin-dependent kinase 16 | PCTAIRE-motif protein kinase 1 | PCTAIRE1 | PCTK1 | Serine/threonine-protein kinase PCTAIRE-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase taire subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 16 SINGLE PROTEIN Q00536

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY
CHEMBL3885550 Cyclin-Y/Cyclin-dependent kinase 16 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102225
Ensembl ENSG00000102225
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0030133 (transport vesicle)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0043005 (neuron projection)
GO:0045202 (synapse)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006887 (exocytosis)
GO:0007283 (spermatogenesis)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0030252 (growth hormone secretion)
GO:0031175 (neuron projection development)
GO:0061178 (regulation of insulin secretion involved in cellular response to glucose stimulus)
Wikipedia PCTK1

Target Cross References - Protein

canSAR Q00536
Human Protein Atlas ENSG00000102225
IntAct Q00536
Guide to Pharmacology 1969
Open Targets ENSG00000102225
PharmGKB PA33095
Pharos Q00536 (Tchem)
UniProt A8K280 B7Z7C8 J3KN74 J3KQP7 Q00536

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3MTL 5G6V
CREDO 3MTL 5G6V
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