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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4592
Target Type SINGLE PROTEIN
Preferred Name Amine oxidase, copper containing
Synonyms Aoc3 | Copper amine oxidase | Membrane primary amine oxidase | SSAO | Semicarbazide-sensitive amine oxidase | VAP-1 | VP97 | Vascular adhesion protein 1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Membrane primary amine oxidase SINGLE PROTEIN O08590

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0005507 (copper ion binding)
GO:0008131 (primary amine oxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0048038 (quinone binding)
GO:0052593 (tryptamine:oxygen oxidoreductase (deaminating) activity)
GO:0052594 (aminoacetone:oxygen oxidoreductase(deaminating) activity)
GO:0052595 (aliphatic-amine oxidase activity)
GO:0052596 (phenethylamine:oxygen oxidoreductase (deaminating) activity)
GO Biological Process GO:0002523 (leukocyte migration involved in inflammatory response)
GO:0002675 (positive regulation of acute inflammatory response)
GO:0002687 (positive regulation of leukocyte migration)
GO:0007155 (cell adhesion)
GO:0007568 (aging)
GO:0008217 (regulation of blood pressure)
GO:0009308 (amine metabolic process)
GO:0010828 (positive regulation of glucose transport)
GO:0035902 (response to immobilization stress)
GO:0042755 (eating behavior)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR O08590
Reactome R-RNO-211945 (Phase 1 - Functionalization of compounds.)
UniProt O08590 Q497D2 Q5R1T5

Target Cross References - Domain

InterPro IPR000269 (Cu_amine_oxidase.)
IPR015798 (Cu_amine_oxidase_C.)
IPR015800 (Cu_amine_oxidase_N2.)
IPR015802 (Cu_amine_oxidase_N3.)
IPR016182 (Cu_amine_oxidase_N-reg.)
Pfam PF01179 (Cu_amine_oxid)
PF02727 (Cu_amine_oxidN2)
PF02728 (Cu_amine_oxidN3)
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