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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4577
Target Type SINGLE PROTEIN
Preferred Name Homeodomain-interacting protein kinase 3
Synonyms ANPK | Androgen receptor-interacting nuclear protein kinase | DYRK6 | FIST | FIST3 | Fas-interacting serine/threonine-protein kinase | HIPK3 | Homeodomain-interacting protein kinase 3 | Homolog of protein kinase YAK1 | PKY
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase dyrk family > cmgc protein kinase hipk subfamily

Target Components

Component Description Relationship Accession
Homeodomain-interacting protein kinase 3 SINGLE PROTEIN Q9H422

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110422
Ensembl ENSG00000110422
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016604 (nuclear body)
GO:0016605 (PML body)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0009299 (mRNA transcription)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043508 (negative regulation of JUN kinase activity)
Wikipedia HIPK3

Target Cross References - Protein

canSAR Q9H422
Human Protein Atlas ENSG00000110422
IntAct Q9H422
Guide to Pharmacology 2035
Open Targets ENSG00000110422
PharmGKB PA29292
Pharos Q9H422 (Tbio)
UniProt O14632 Q2PBG4 Q2PBG5 Q92632 Q9H422 Q9HAS2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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