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Target Report Card

Target Name and Classification

Target ID CHEMBL4576
Preferred Name Homeodomain-interacting protein kinase 2
Synonyms HIPK2 | Homeodomain-interacting protein kinase 2 | hHIPk2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase dyrk family > cmgc protein kinase hipk subfamily

Target Components

Component Description Relationship Accession
Homeodomain-interacting protein kinase 2 SINGLE PROTEIN Q9H2X6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000064393
Ensembl ENSG00000064393
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0016604 (nuclear body)
GO:0016605 (PML body)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0001105 (RNA polymerase II transcription coactivator activity)
GO:0003714 (transcription corepressor activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046332 (SMAD binding)
GO:0046790 (virion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001654 (eye development)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006978 (DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007224 (smoothened signaling pathway)
GO:0007628 (adult walking behavior)
GO:0008284 (positive regulation of cell proliferation)
GO:0008344 (adult locomotory behavior)
GO:0009952 (anterior/posterior pattern specification)
GO:0010842 (retina layer formation)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0019048 (modulation by virus of host morphology or physiology)
GO:0030182 (neuron differentiation)
GO:0030218 (erythrocyte differentiation)
GO:0030511 (positive regulation of transforming growth factor beta receptor signaling pathway)
GO:0030514 (negative regulation of BMP signaling pathway)
GO:0030578 (PML body organization)
GO:0032092 (positive regulation of protein binding)
GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
GO:0043388 (positive regulation of DNA binding)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045766 (positive regulation of angiogenesis)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046330 (positive regulation of JNK cascade)
GO:0048596 (embryonic camera-type eye morphogenesis)
GO:0050882 (voluntary musculoskeletal movement)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051726 (regulation of cell cycle)
GO:0060059 (embryonic retina morphogenesis in camera-type eye)
GO:0060235 (lens induction in camera-type eye)
GO:0060395 (SMAD protein signal transduction)
GO:0061072 (iris morphogenesis)
GO:0071456 (cellular response to hypoxia)
GO:0097193 (intrinsic apoptotic signaling pathway)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:2000059 (negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
Wikipedia HIPK2

Target Cross References - Protein

canSAR Q9H2X6
Human Protein Atlas ENSG00000064393
IntAct Q9H2X6
Guide to Pharmacology 2034
Open Targets ENSG00000064393
PharmGKB PA29291
Pharos Q9H2X6 (Tchem)
Reactome R-HSA-2032785 (YAP1- and WWTR1 (TAZ)-stimulated gene expression.)
R-HSA-5578768 (Physiological factors.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-8939243 (RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.)
UniProt Q75MR7 Q8WWI4 Q9H2X6 Q9H2Y1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)