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Target Report Card

Target Name and Classification

Target ID CHEMBL4574
Preferred Name BR serine/threonine-protein kinase 2
Synonyms BR serine/threonine-protein kinase 2 | BRSK2 | Brain-selective kinase 2 | Brain-specific serine/threonine-protein kinase 2 | C11orf7 | PEN11B | SADA | STK29 | Serine/threonine-protein kinase 29 | Serine/threonine-protein kinase BRSK2 | Serine/threonine-protein kinase SAD-A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase brsk subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase BRSK2 SINGLE PROTEIN Q8IWQ3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000174672
Ensembl ENSG00000174672
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005856 (cytoskeleton)
GO:0048471 (perinuclear region of cytoplasm)
GO:0150034 (distal axon)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0046872 (metal ion binding)
GO:0050321 (tau-protein kinase activity)
GO:0051117 (ATPase binding)
GO:0060590 (ATPase regulator activity)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0006887 (exocytosis)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007399 (nervous system development)
GO:0007409 (axonogenesis)
GO:0010975 (regulation of neuron projection development)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030010 (establishment of cell polarity)
GO:0030182 (neuron differentiation)
GO:0031532 (actin cytoskeleton reorganization)
GO:0036503 (ERAD pathway)
GO:0043462 (regulation of ATPase activity)
GO:0048812 (neuron projection morphogenesis)
GO:0050770 (regulation of axonogenesis)
GO:0051301 (cell division)
GO:0061178 (regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0090176 (microtubule cytoskeleton organization involved in establishment of planar polarity)
GO:1904152 (regulation of retrograde protein transport, ER to cytosol)
GO:2000807 (regulation of synaptic vesicle clustering)
Wikipedia BRSK2

Target Cross References - Protein

Human Protein Atlas ENSG00000174672
IntAct Q8IWQ3
Guide to Pharmacology 1947
Open Targets ENSG00000174672
PharmGKB PA36212
Pharos Q8IWQ3 (Tchem)
UniProt B3KVE9 E9PLM7 O60843 O95099 Q5J5B4 Q6ZMQ4 Q8IWQ3 Q8TB60

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)