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Target Report Card

Target Name and Classification

Target ID CHEMBL4573
Preferred Name Metabotropic glutamate receptor 6
Synonyms GPRC1F | GRM6 | MGLUR6 | Metabotropic glutamate receptor 6 | mGluR6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family c g protein-coupled receptor > small molecule receptor (family c gpcr) > neurotransmitter receptor (family c gpcr) > metabotropic glutamate receptor

Target Components

Component Description Relationship Accession
Metabotropic glutamate receptor 6 SINGLE PROTEIN O15303

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113262
Ensembl ENSG00000113262
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0035841 (new growing cell tip)
GO:0042734 (presynaptic membrane)
GO:0042995 (cell projection)
GO Molecular Function GO:0001640 (adenylate cyclase inhibiting G-protein coupled glutamate receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0008066 (glutamate receptor activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007196 (adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway)
GO:0007216 (G-protein coupled glutamate receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007601 (visual perception)
GO:0007626 (locomotory behavior)
GO:0009584 (detection of visible light)
GO:0050896 (response to stimulus)
GO:0050908 (detection of light stimulus involved in visual perception)
GO:0050953 (sensory perception of light stimulus)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:0060041 (retina development in camera-type eye)
GO:0090280 (positive regulation of calcium ion import)
Wikipedia Metabotropic_glutamate_receptor_6

Target Cross References - Protein

canSAR O15303
CGD Night blindness, congenital stationary, type 1B
Human Protein Atlas ENSG00000113262
Guide to Pharmacology 294
Open Targets ENSG00000113262
PharmGKB PA28995
Pharos O15303 (Tchem)
Reactome R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-420499 (Class C/3 (Metabotropic glutamate/pheromone receptors).)
UniProt O15303

Target Cross References - Domain

InterPro IPR000112 (GPCR_3_mtglu_rcpt_6.)
IPR000162 (GPCR_3_mtglu_rcpt.)
IPR000337 (GPCR_3.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR011500 (GPCR_3_9-Cys_dom.)
IPR017978 (GPCR_3_C.)
IPR017979 (GPCR_3_CS.)
IPR028082 (Peripla_BP_I.)
Pfam PF00003 (7tm_3)
PF01094 (ANF_receptor)
PF07562 (NCD3G)