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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4572
Target Type SINGLE PROTEIN
Preferred Name Muscarinic acetylcholine receptor M4
Synonyms Chrm-4 | Chrm4 | Mm4 mAChR | Muscarinic acetylcholine receptor M4
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M4 SINGLE PROTEIN P32211

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097162 Muscarinic acetylcholine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0032279 (asymmetric synapse)
GO:0042383 (sarcolemma)
GO:0043025 (neuronal cell body)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0010033 (response to organic substance)
GO:0040012 (regulation of locomotion)
GO:0043547 (positive regulation of GTPase activity)

Target Cross References - Protein

canSAR P32211
IntAct P32211
Reactome R-MMU-390648 (Muscarinic acetylcholine receptors.)
R-MMU-418594 (G alpha (i) signalling events.)
UniProt P32211 Q64056

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000995 (Musac_Ach_rcpt.)
IPR001432 (Musac_Ach_M4_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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