ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL4533
Target Type SINGLE PROTEIN
Preferred Name AMP-activated protein kinase, alpha-1 subunit
Synonyms 5'-AMP-activated protein kinase catalytic subunit alpha-1 | ACACA kinase | AMPK subunit alpha-1 | Acetyl-CoA carboxylase kinase | Ampk1 | HMGCR kinase | Hydroxymethylglutaryl-CoA reductase kinase | Prkaa1 | Tau-protein kinase PRKAA1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase ampk subfamily

Target Components

Component Description Relationship Accession
5'-AMP-activated protein kinase catalytic subunit alpha-1 SINGLE PROTEIN P54645

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0016324 (apical plasma membrane)
GO:0031588 (nucleotide-activated protein kinase complex)
GO:0043234 (protein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003682 (chromatin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004679 (AMP-activated protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019900 (kinase binding)
GO:0035174 (histone serine kinase activity)
GO:0042557 (eukaryotic elongation factor-2 kinase activator activity)
GO:0046872 (metal ion binding)
GO:0047322 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity)
GO:0050321 (tau-protein kinase activity)
GO:0050405 ([acetyl-CoA carboxylase] kinase activity)
GO Biological Process GO:0006006 (glucose metabolic process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006694 (steroid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0006914 (autophagy)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0008610 (lipid biosynthetic process)
GO:0009411 (response to UV)
GO:0009631 (cold acclimation)
GO:0010332 (response to gamma radiation)
GO:0010508 (positive regulation of autophagy)
GO:0010628 (positive regulation of gene expression)
GO:0014823 (response to activity)
GO:0016055 (Wnt signaling pathway)
GO:0016126 (sterol biosynthetic process)
GO:0016310 (phosphorylation)
GO:0016568 (chromatin modification)
GO:0017148 (negative regulation of translation)
GO:0019395 (fatty acid oxidation)
GO:0031000 (response to caffeine)
GO:0031669 (cellular response to nutrient levels)
GO:0032007 (negative regulation of TOR signaling)
GO:0032147 (activation of protein kinase activity)
GO:0033135 (regulation of peptidyl-serine phosphorylation)
GO:0035404 (histone-serine phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0042149 (cellular response to glucose starvation)
GO:0042542 (response to hydrogen peroxide)
GO:0042593 (glucose homeostasis)
GO:0042752 (regulation of circadian rhythm)
GO:0043066 (negative regulation of apoptotic process)
GO:0045722 (positive regulation of gluconeogenesis)
GO:0045821 (positive regulation of glycolytic process)
GO:0046321 (positive regulation of fatty acid oxidation)
GO:0046326 (positive regulation of glucose import)
GO:0048511 (rhythmic process)
GO:0048643 (positive regulation of skeletal muscle tissue development)
GO:0050995 (negative regulation of lipid catabolic process)
GO:0051291 (protein heterooligomerization)
GO:0055089 (fatty acid homeostasis)
GO:0060627 (regulation of vesicle-mediated transport)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071361 (cellular response to ethanol)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:0071417 (cellular response to organonitrogen compound)
GO:0071456 (cellular response to hypoxia)
GO:1901563 (response to camptothecin)
GO:2000505 (regulation of energy homeostasis)
GO:2001274 (negative regulation of glucose import in response to insulin stimulus)

Target Cross References - Protein

canSAR P54645
IntAct P54645
Reactome R-RNO-1632852 (Macroautophagy.)
R-RNO-380972 (Energy dependent regulation of mTOR by LKB1-AMPK.)
R-RNO-5628897 (TP53 Regulates Metabolic Genes.)
R-RNO-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt P54645

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028375 (KA1/Ssp2_C.)
IPR032270 (AMPK_C.)
Pfam PF00069 (Pkinase)
PF16579 (AdenylateSensor)

Target Cross References - Structure

PDBe 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4EAK 4EAL 4F2L 4QFG 4QFR 4QFS 5KQ5
CREDO 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4EAK 4EAL 4F2L 4QFG 4QFR 4QFS 5KQ5
spacer
spacer