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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4527
Target Type SINGLE PROTEIN
Preferred Name TRAF2- and NCK-interacting kinase
Synonyms KIAA0551 | TNIK | TRAF2 and NCK-interacting protein kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase msn subfamily

Target Components

Component Description Relationship Accession
TRAF2 and NCK-interacting protein kinase SINGLE PROTEIN Q9UKE5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000154310
Ensembl ENSG00000154310
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0016324 (apical plasma membrane)
GO:0055037 (recycling endosome)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008349 (MAP kinase kinase kinase kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000185 (activation of MAPKKK activity)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0007010 (cytoskeleton organization)
GO:0007256 (activation of JNKK activity)
GO:0007346 (regulation of mitotic cell cycle)
GO:0007399 (nervous system development)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
GO:0030033 (microvillus assembly)
GO:0031532 (actin cytoskeleton reorganization)
GO:0035556 (intracellular signal transduction)
GO:0042981 (regulation of apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:0048814 (regulation of dendrite morphogenesis)
GO:0072659 (protein localization to plasma membrane)
Wikipedia TNIK

Target Cross References - Protein

canSAR Q9UKE5
Human Protein Atlas ENSG00000154310
IntAct Q9UKE5
Guide to Pharmacology 2244
Open Targets ENSG00000154310
PharmGKB PA134893180
Pharos Q9UKE5 (Tchem)
Reactome R-HSA-2559580 (Oxidative Stress Induced Senescence.)
UniProt A7E2A3 A8K4U1 D3DNQ6 O60298 Q8WUY7 Q9UKD8 Q9UKD9 Q9UKE0 Q9UKE1 Q9UKE2 Q9UKE3 Q9UKE4 Q9UKE5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001180 (CNH_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF00780 (CNH)

Target Cross References - Structure

PDBe 2X7F 5AX9 5CWZ 5D7A
CREDO 2X7F 5AX9 5CWZ 5D7A
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