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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4526
Target Type SINGLE PROTEIN
Preferred Name Ephrin type-A receptor 6
Synonyms EHK-2 | EHK2 | EK12 | EPH homology kinase 2 | EPH-like kinase 12 | EPHA6 | Ephrin type-A receptor 6 | HEK12
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-A receptor 6 SINGLE PROTEIN Q9UF33

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000080224
Ensembl ENSG00000080224
GO Cellular Component GO:0005575 (cellular_component)
GO:0005654 (nucleoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003674 (molecular_function)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005003 (ephrin receptor activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0008150 (biological_process)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
Wikipedia EPHA6

Target Cross References - Protein

canSAR Q9UF33
Human Protein Atlas ENSG00000080224
Guide to Pharmacology 1826
Open Targets ENSG00000080224
PharmGKB PA134866684
Pharos Q9UF33 (Tchem)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt D6RAL5 Q9UF33

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like_sf.)
IPR009030 (Growth_fac_rcpt_cys_sf.)
IPR011009 (Kinase-like_dom_sf.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed_sf.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027936 (Eph_TM.)
IPR034280 (EphA6_rcpt_lig-bd.)
IPR036116 (FN3_sf.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)
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