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Target Report Card

Target Name and Classification

Target ID CHEMBL4524
Preferred Name Serine/threonine-protein kinase PAK7
Synonyms KIAA1264 | PAK-5 | PAK-7 | PAK5 | PAK7 | Serine/threonine-protein kinase PAK 5 | p21-activated kinase 5 | p21-activated kinase 7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase pakb subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 5 SINGLE PROTEIN Q9P286

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101349
Ensembl ENSG00000101349
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0048365 (Rac GTPase binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007010 (cytoskeleton organization)
GO:0007165 (signal transduction)
GO:0007266 (Rho protein signal transduction)
GO:0007346 (regulation of mitotic cell cycle)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0007626 (locomotory behavior)
GO:0008283 (cell proliferation)
GO:0016049 (cell growth)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030036 (actin cytoskeleton organization)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0032147 (activation of protein kinase activity)
GO:0042981 (regulation of apoptotic process)
GO:0043408 (regulation of MAPK cascade)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia PAK7

Target Cross References - Protein

canSAR Q9P286
Human Protein Atlas ENSG00000101349
IntAct Q9P286
Guide to Pharmacology 2138
Open Targets ENSG00000101349
PharmGKB PA32922
Pharos Q9P286 (Tchem)
Reactome R-HSA-428540 (Activation of RAC1.)
UniProt A8K5T6 D3DW14 Q5W115 Q8TB93 Q9BX09 Q9P286 Q9ULF6

Target Cross References - Domain

InterPro IPR000095 (CRIB_dom.)
IPR000719 (Prot_kinase_dom.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028754 (PAK5.)
IPR033923 (PAK_BD.)
IPR036936 (CRIB_dom_sf.)
Pfam PF00069 (Pkinase)
PF00786 (PBD)

Target Cross References - Structure

PDBe 2F57