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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4516
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase MRCK-A
Synonyms CDC42-binding protein kinase alpha | CDC42BPA | DMPK-like alpha | KIAA0451 | MRCK alpha | Myotonic dystrophy kinase-related CDC42-binding kinase alpha | Myotonic dystrophy protein kinase-like alpha | Serine/threonine-protein kinase MRCK alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase dmpk family > agc protein kinase gek subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase MRCK alpha SINGLE PROTEIN Q5VT25

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143776
Ensembl ENSG00000143776
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005911 (cell-cell junction)
GO:0030027 (lamellipodium)
GO:0031252 (cell leading edge)
GO:0042641 (actomyosin)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0030036 (actin cytoskeleton organization)
GO:0031032 (actomyosin structure organization)
GO:0031532 (actin cytoskeleton reorganization)
GO:0035556 (intracellular signal transduction)
Wikipedia CDC42BPA

Target Cross References - Protein

canSAR Q5VT25
Human Protein Atlas ENSG00000143776
IntAct Q5VT25
Guide to Pharmacology 1507
Open Targets ENSG00000143776
PharmGKB PA26267
Pharos Q5VT25 (Tchem)
UniProt O75039 Q59GZ1 Q5H9N9 Q5T797 Q5VT25 Q5VT26 Q5VT27 Q86XX2 Q86XX3 Q99646

Target Cross References - Domain

InterPro IPR000095 (CRIB_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001180 (CNH_dom.)
IPR001849 (PH_domain.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011993 (PH-like_dom_sf.)
IPR014930 (Myotonic_dystrophy_kinase_coil.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR026611 (Ser/Thr_kinase_MRCK_alpha.)
IPR031597 (KELK.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00433 (Pkinase_C)
PF00780 (CNH)
PF08826 (DMPK_coil)
PF15796 (KELK)
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