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Target Report Card

Target Name and Classification

Target ID CHEMBL4503
Preferred Name Nociceptin receptor
Synonyms KOR-3 | Kappa-type 3 opioid receptor | Nociceptin receptor | Oor | Oprl | Oprl1 | Orphanin FQ receptor | ROR-C | XOR1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > opioid receptor

Target Components

Component Description Relationship Accession
Nociceptin receptor SINGLE PROTEIN P35370

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038507 Nociceptin/mu opioid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0043005 (neuron projection)
GO Molecular Function GO:0001626 (nociceptin receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004985 (opioid receptor activity)
GO:0008022 (protein C-terminus binding)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007610 (behavior)
GO:0019233 (sensory perception of pain)
GO:0032355 (response to estradiol)
GO:0035810 (positive regulation of urine volume)
GO:0038003 (opioid receptor signaling pathway)
GO:0042755 (eating behavior)
GO:0043951 (negative regulation of cAMP-mediated signaling)
GO:0044849 (estrous cycle)
GO:0045776 (negative regulation of blood pressure)
GO:0051930 (regulation of sensory perception of pain)
GO:0060454 (positive regulation of gastric acid secretion)
GO:0106072 (negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:1901386 (negative regulation of voltage-gated calcium channel activity)
GO:1904058 (positive regulation of sensory perception of pain)
GO:1904059 (regulation of locomotor rhythm)

Target Cross References - Protein

canSAR P35370
Guide to Pharmacology 320
Reactome R-RNO-375276 (Peptide ligand-binding receptors.)
R-RNO-418594 (G alpha (i) signalling events.)
UniProt P35370 Q791R4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001418 (Opioid_rcpt.)
IPR001420 (X_opioid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)