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Target Report Card

Target Name and Classification

Target ID CHEMBL4501
Preferred Name Ribosomal protein S6 kinase 1
Synonyms 70 kDa ribosomal protein S6 kinase 1 | P70S6K1 | RPS6KB1 | Ribosomal protein S6 kinase I | Ribosomal protein S6 kinase beta-1 | S6K-beta-1 | S6K1 | STK14A | Serine/threonine-protein kinase 14A | p70 S6 kinase alpha | p70 S6K-alpha | p70 S6KA | p70 ribosomal S6 kinase alpha | p70-S6K 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase p70 subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase beta-1 SINGLE PROTEIN P23443

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111330 Ribosomal protein S6 kinase (P70S6K) PROTEIN COMPLEX
CHEMBL3885629 RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 PROTEIN FAMILY
CHEMBL3832633 Ribosomal protein S6 kinase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545076 LY-2584702 Ribosomal protein S6 kinase 1 inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108443
Ensembl ENSG00000108443
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0043005 (neuron projection)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004711 (ribosomal protein S6 kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030165 (PDZ domain binding)
GO:0042277 (peptide binding)
GO:0042802 (identical protein binding)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0001662 (behavioral fear response)
GO:0003009 (skeletal muscle contraction)
GO:0006417 (regulation of translation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0007281 (germ cell development)
GO:0007568 (aging)
GO:0007584 (response to nutrient)
GO:0007616 (long-term memory)
GO:0009408 (response to heat)
GO:0009611 (response to wounding)
GO:0009612 (response to mechanical stimulus)
GO:0009636 (response to toxic substance)
GO:0009749 (response to glucose)
GO:0010033 (response to organic substance)
GO:0010243 (response to organonitrogen compound)
GO:0014070 (response to organic cyclic compound)
GO:0014732 (skeletal muscle atrophy)
GO:0014878 (response to electrical stimulus involved in regulation of muscle adaptation)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0031929 (TOR signaling)
GO:0032496 (response to lipopolysaccharide)
GO:0032868 (response to insulin)
GO:0032869 (cellular response to insulin stimulus)
GO:0032870 (cellular response to hormone stimulus)
GO:0033574 (response to testosterone)
GO:0033762 (response to glucagon)
GO:0034612 (response to tumor necrosis factor)
GO:0042493 (response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0043200 (response to amino acid)
GO:0043201 (response to leucine)
GO:0043434 (response to peptide hormone)
GO:0043491 (protein kinase B signaling)
GO:0045471 (response to ethanol)
GO:0045727 (positive regulation of translation)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0045948 (positive regulation of translational initiation)
GO:0046324 (regulation of glucose import)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048633 (positive regulation of skeletal muscle tissue growth)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051384 (response to glucocorticoid)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia P70-S6_Kinase_1

Target Cross References - Protein

canSAR P23443
Human Protein Atlas ENSG00000108443
IntAct P23443
Guide to Pharmacology 1525
Open Targets ENSG00000108443
PharmGKB PA34851
Pharos P23443 (Tchem)
Reactome R-HSA-166208 (mTORC1-mediated signalling.)
UniProt B2R779 B4DLT4 B4DTG1 E7ESB8 F6UYM1 P23443 Q7Z721

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016238 (Ribosomal_S6_kinase.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK
CREDO 3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK