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Target Report Card

Target Name and Classification

Target ID CHEMBL4487
Preferred Name Serine/threonine-protein kinase PAK 2
Synonyms C-t-PAK2 | Gamma-PAK | PAK-2 | PAK-2p27 | PAK-2p34 | PAK2 | PAK65 | S6/H4 kinase | Serine/threonine-protein kinase PAK 2 | p21-activated kinase 2 | p27 | p34 | p58
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase paka subfamily

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase PAK 2 SINGLE PROTEIN Q13177

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885637 Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 PROTEIN FAMILY
CHEMBL3885636 Serine/threonine-protein kinase PAK 1/PAK 2 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180370
Ensembl ENSG00000180370
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0030296 (protein tyrosine kinase activator activity)
GO:0031267 (small GTPase binding)
GO:0042802 (identical protein binding)
GO:0045296 (cadherin binding)
GO:0048365 (Rac GTPase binding)
GO Biological Process GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007266 (Rho protein signal transduction)
GO:0007346 (regulation of mitotic cell cycle)
GO:0008152 (metabolic process)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030036 (actin cytoskeleton organization)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0031295 (T cell costimulation)
GO:0035722 (interleukin-12-mediated signaling pathway)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0040008 (regulation of growth)
GO:0042981 (regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043408 (regulation of MAPK cascade)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0050690 (regulation of defense response to virus by virus)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050852 (T cell receptor signaling pathway)
GO:0060996 (dendritic spine development)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0071407 (cellular response to organic cyclic compound)
GO:2001238 (positive regulation of extrinsic apoptotic signaling pathway)
GO:2001271 (negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)
Wikipedia PAK2

Target Cross References - Protein

canSAR Q13177
Human Protein Atlas ENSG00000180370
IntAct Q13177
Guide to Pharmacology 2134
Open Targets ENSG00000180370
PharmGKB PA32918
Pharos Q13177 (Tchem)
Reactome R-HSA-164944 (Nef and signal transduction.)
R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-211728 (Regulation of PAK-2p34 activity by PS-GAP/RHG10.)
R-HSA-211733 (Regulation of activated PAK-2p34 by proteasome mediated degradation.)
R-HSA-211736 (Stimulation of the cell death response by PAK-2p34.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-389359 (CD28 dependent Vav1 pathway.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-428540 (Activation of RAC1.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-445355 (Smooth Muscle Contraction.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5627123 (RHO GTPases activate PAKs.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-8950505 (Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation.)
UniProt Q13154 Q13177 Q6ISC3

Target Cross References - Domain

InterPro IPR000095 (CRIB_dom.)
IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR033923 (PAK_BD.)
IPR035064 (STK_PAK2.)
IPR035065 (PAK2/3.)
IPR036936 (CRIB_dom_sf.)
Pfam PF00069 (Pkinase)
PF00786 (PBD)

Target Cross References - Structure