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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4478
Target Type SINGLE PROTEIN
Preferred Name Voltage-gated N-type calcium channel alpha-1B subunit
Synonyms BIII | Brain calcium channel III | CACH5 | CACNA1B | CACNL1A5 | Calcium channel, L type, alpha-1 polypeptide isoform 5 | Voltage-dependent N-type calcium channel subunit alpha-1B | Voltage-gated calcium channel subunit alpha Cav2.2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent N-type calcium channel subunit alpha-1B SINGLE PROTEIN Q00975

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097170 Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 PROTEIN-PROTEIN INTERACTION
CHEMBL2363032 Voltage-gated calcium channel PROTEIN COMPLEX GROUP
CHEMBL3430901 Voltage-dependent N-type calcium channel subunit alpha-1B/Voltage-dependent calcium channel subunit alpha-2/delta-1/Voltage-dependent L-type calcium channel subunit beta-3 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1286 LEVETIRACETAM Voltage-gated N-type calcium channel alpha-1B subunit blocker 4 DailyMed
CHEMBL1795072 ZICONOTIDE ACETATE Voltage-gated N-type calcium channel alpha-1B subunit blocker 4 FDA PubMed
CHEMBL2107771 RALFINAMIDE Voltage-gated N-type calcium channel alpha-1B subunit blocker 3 Other PubMed
CHEMBL604710 Z160 Voltage-gated N-type calcium channel alpha-1B subunit blocker 2 PubMed
CHEMBL3545172 CNV2197944 Voltage-gated N-type calcium channel alpha-1B subunit blocker 2 Other Other
CHEMBL29919 ELPETRIGINE Voltage-gated N-type calcium channel alpha-1B subunit blocker 0 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000148408
Ensembl ENSG00000148408
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0045202 (synapse)
GO:0098793 (presynapse)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0008331 (high voltage-gated calcium channel activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0007269 (neurotransmitter secretion)
GO:0007626 (locomotory behavior)
GO:0008016 (regulation of heart contraction)
GO:0008217 (regulation of blood pressure)
GO:0034765 (regulation of ion transmembrane transport)
GO:0048265 (response to pain)
GO:0051899 (membrane depolarization)
GO:0051924 (regulation of calcium ion transport)
GO:0055085 (transmembrane transport)
GO:0070588 (calcium ion transmembrane transport)
GO:0086010 (membrane depolarization during action potential)
Wikipedia N-type_calcium_channel

Target Cross References - Protein

canSAR Q00975
Human Protein Atlas ENSG00000148408
IntAct Q00975
Guide to Pharmacology 533
Open Targets ENSG00000148408
PharmGKB PA26008
Pharos Q00975 (Tclin)
Reactome R-HSA-112308 (Presynaptic depolarization and calcium channel opening.)
TIMBAL BIII
UniProt B1AQK5 Q00975

Target Cross References - Domain

InterPro IPR002048 (EF_hand_dom.)
IPR002077 (VDCCAlpha1.)
IPR005447 (VDCC_N_a1su.)
IPR005821 (Ion_trans_dom.)
IPR014873 (VDCC_a1su_IQ.)
IPR027359 (Volt_channel_dom_sf.)
IPR031649 (GPHH_dom.)
Pfam PF00520 (Ion_trans)
PF08763 (Ca_chan_IQ)
PF16905 (GPHH)
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