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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4457
Preferred Name Neuronal acetylcholine receptor protein alpha-4 subunit
Synonyms Acra4 | Chrna4 | Neuronal acetylcholine receptor subunit alpha-4
Organism Mus musculus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-4 SINGLE PROTEIN O70174

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3350222 Neuronal nicotinic acetylcholine receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004889 (acetylcholine-activated cation-selective channel activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005515 (protein binding)
GO:0015464 (acetylcholine receptor activity)
GO:0042166 (acetylcholine binding)
GO Biological Process GO:0001508 (action potential)
GO:0001666 (response to hypoxia)
GO:0006281 (DNA repair)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006979 (response to oxidative stress)
GO:0007165 (signal transduction)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007274 (neuromuscular synaptic transmission)
GO:0007585 (respiratory gaseous exchange)
GO:0007626 (locomotory behavior)
GO:0014059 (regulation of dopamine secretion)
GO:0019233 (sensory perception of pain)
GO:0035094 (response to nicotine)
GO:0035095 (behavioral response to nicotine)
GO:0035640 (exploration behavior)
GO:0042113 (B cell activation)
GO:0042391 (regulation of membrane potential)
GO:0050877 (neurological system process)
GO:0050890 (cognition)
GO:0051899 (membrane depolarization)
GO:0060080 (inhibitory postsynaptic potential)
GO:0095500 (acetylcholine receptor signaling pathway)
GO:0098655 (cation transmembrane transport)

Target Cross References - Protein

canSAR O70174
Reactome R-MMU-629587 (Highly sodium permeable acetylcholine nicotinic receptors.)
R-MMU-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
R-MMU-629597 (Highly calcium permeable nicotinic acetylcholine receptors.)
UniProt O70174 Q8BHE9 Q8VI10 Q9ET51

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR027361 (Acetylcholine_rcpt_TM.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)