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Target Report Card

Target Name and Classification

Target ID CHEMBL4454
Preferred Name Tyrosine-protein kinase FGR
Synonyms FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC2 | Tyrosine-protein kinase Fgr | p55-Fgr | p58-Fgr | p58c-Fgr
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Fgr SINGLE PROTEIN P09769

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000000938
Ensembl ENSG00000000938
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005758 (mitochondrial intermembrane space)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0015629 (actin cytoskeleton)
GO:0016020 (membrane)
GO:0016235 (aggresome)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0032587 (ruffle membrane)
GO:0034774 (secretory granule lumen)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001784 (phosphotyrosine binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0034987 (immunoglobulin receptor binding)
GO:0034988 (Fc-gamma receptor I complex binding)
GO Biological Process GO:0002376 (immune system process)
GO:0002768 (immune response-regulating cell surface receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007229 (integrin-mediated signaling pathway)
GO:0008360 (regulation of cell shape)
GO:0009615 (response to virus)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042127 (regulation of cell proliferation)
GO:0043306 (positive regulation of mast cell degranulation)
GO:0043312 (neutrophil degranulation)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045087 (innate immune response)
GO:0045088 (regulation of innate immune response)
GO:0045859 (regulation of protein kinase activity)
GO:0046777 (protein autophosphorylation)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050764 (regulation of phagocytosis)
GO:0050830 (defense response to Gram-positive bacterium)
Wikipedia FGR_(gene)

Target Cross References - Protein

canSAR P09769
Human Protein Atlas ENSG00000000938
IntAct P09769
Guide to Pharmacology 2024
Open Targets ENSG00000000938
PharmGKB PA28135
Pharos P09769 (Tchem)
Reactome R-HSA-2029481 (FCGR activation.)
R-HSA-432142 (Platelet sensitization by LDL.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt D3DPL7 P09769 Q9UIQ3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR035693 (Fgr_SH2.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)