ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4430
Preferred Name Cytochrome P450 17A1
Synonyms 17-alpha-hydroxyprogesterone aldolase | CYPXVII | Cyp17 | Cyp17a1 | Cytochrome P450 17A1 | Cytochrome P450-C17 | Cytochrome P450c17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 17 > cytochrome p450 family 17a > cytochrome p450 17a1

Target Components

Component Description Relationship Accession
Steroid 17-alpha-hydroxylase/17,20 lyase SINGLE PROTEIN P11715

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0016020 (membrane)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004508 (steroid 17-alpha-monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016829 (lyase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0047442 (17-alpha-hydroxyprogesterone aldolase activity)
GO Biological Process GO:0006082 (organic acid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006702 (androgen biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0008584 (male gonad development)
GO:0009635 (response to herbicide)
GO:0009636 (response to toxic substance)
GO:0010033 (response to organic substance)
GO:0010034 (response to acetate)
GO:0010212 (response to ionizing radiation)
GO:0014070 (response to organic cyclic compound)
GO:0017085 (response to insecticide)
GO:0018879 (biphenyl metabolic process)
GO:0018894 (dibenzo-p-dioxin metabolic process)
GO:0018958 (phenol-containing compound metabolic process)
GO:0018963 (phthalate metabolic process)
GO:0021766 (hippocampus development)
GO:0030325 (adrenal gland development)
GO:0030728 (ovulation)
GO:0031667 (response to nutrient levels)
GO:0032526 (response to retinoic acid)
GO:0033327 (Leydig cell differentiation)
GO:0034097 (response to cytokine)
GO:0034698 (response to gonadotropin)
GO:0042446 (hormone biosynthetic process)
GO:0042448 (progesterone metabolic process)
GO:0042493 (response to drug)
GO:0048545 (response to steroid hormone)
GO:0051591 (response to cAMP)
GO:0051597 (response to methylmercury)
GO:0055114 (oxidation-reduction process)
GO:0060992 (response to fungicide)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071236 (cellular response to antibiotic)
GO:0071371 (cellular response to gonadotropin stimulus)
GO:0090031 (positive regulation of steroid hormone biosynthetic process)

Target Cross References - Protein

canSAR P11715
UniProt P11715 Q68FY2 Q6LAE5

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)