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Target Report Card

Target Name and Classification

Target ID CHEMBL4426
Preferred Name Phospholipase A2 group 1B
Synonyms Group IB phospholipase A2 | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phospholipase A2 SINGLE PROTEIN P04054

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170890
Ensembl ENSG00000170890
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005829 (cytosol)
GO:0009986 (cell surface)
GO:0030141 (secretory granule)
GO Molecular Function GO:0004623 (phospholipase A2 activity)
GO:0005102 (receptor binding)
GO:0005509 (calcium ion binding)
GO:0016787 (hydrolase activity)
GO:0032052 (bile acid binding)
GO:0046872 (metal ion binding)
GO:0047498 (calcium-dependent phospholipase A2 activity)
GO:0102567 (phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine))
GO:0102568 (phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine))
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0002227 (innate immune response in mucosa)
GO:0002446 (neutrophil mediated immunity)
GO:0006629 (lipid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006644 (phospholipid metabolic process)
GO:0006654 (phosphatidic acid biosynthetic process)
GO:0007015 (actin filament organization)
GO:0007165 (signal transduction)
GO:0008284 (positive regulation of cell proliferation)
GO:0010524 (positive regulation of calcium ion transport into cytosol)
GO:0016042 (lipid catabolic process)
GO:0019370 (leukotriene biosynthetic process)
GO:0019731 (antibacterial humoral response)
GO:0030593 (neutrophil chemotaxis)
GO:0032431 (activation of phospholipase A2 activity)
GO:0032637 (interleukin-8 production)
GO:0032869 (cellular response to insulin stimulus)
GO:0035556 (intracellular signal transduction)
GO:0036148 (phosphatidylglycerol acyl-chain remodeling)
GO:0036149 (phosphatidylinositol acyl-chain remodeling)
GO:0036150 (phosphatidylserine acyl-chain remodeling)
GO:0036151 (phosphatidylcholine acyl-chain remodeling)
GO:0036152 (phosphatidylethanolamine acyl-chain remodeling)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046324 (regulation of glucose import)
GO:0046470 (phosphatidylcholine metabolic process)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0050482 (arachidonic acid secretion)
GO:0050714 (positive regulation of protein secretion)
GO:0050778 (positive regulation of immune response)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0061844 (antimicrobial humoral immune response mediated by antimicrobial peptide)
Wikipedia PLA2G1B

Target Cross References - Protein

canSAR P04054
Human Protein Atlas ENSG00000170890
IntAct P04054
Guide to Pharmacology 1416
Open Targets ENSG00000170890
PharmGKB PA33361
Reactome R-HSA-1482788 (Acyl chain remodelling of PC.)
R-HSA-1482801 (Acyl chain remodelling of PS.)
R-HSA-1482839 (Acyl chain remodelling of PE.)
R-HSA-1482922 (Acyl chain remodelling of PI.)
R-HSA-1482925 (Acyl chain remodelling of PG.)
R-HSA-1483166 (Synthesis of PA.)
UniProt B2R4H5 P04054 Q3KPI1

Target Cross References - Domain

InterPro IPR001211 (PLipase_A2.)
IPR016090 (PLipase_A2_dom.)
IPR033112 (PLipase_A2_Asp_AS.)
IPR033113 (PLipase_A2_His_AS.)
IPR036444 (PLipase_A2_dom_sf.)
Pfam PF00068 (Phospholip_A2_1)

Target Cross References - Structure