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Target Report Card

Target Name and Classification

Target ID CHEMBL4384
Target Type SINGLE PROTEIN
Preferred Name Beta-1,4-galactosyltransferase 1
Synonyms B4GALT1 | Beta-1,4-GalTase 1 | Beta-1,4-galactosyltransferase 1 | Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase | Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase | Beta4Gal-T1 | GGTB2 | Lactose synthase A protein | N-acetyllactosamine synthase | Nal synthase | Processed beta-1,4-galactosyltransferase 1 | UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 | UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1 | b4Gal-T1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Beta-1,4-galactosyltransferase 1 SINGLE PROTEIN P15291

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000086062
Ensembl ENSG00000086062
GO Cellular Component GO:0000138 (Golgi trans cisterna)
GO:0000139 (Golgi membrane)
GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030057 (desmosome)
GO:0030112 (glycocalyx)
GO:0030175 (filopodium)
GO:0031526 (brush border membrane)
GO:0032580 (Golgi cisterna membrane)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003831 (beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity)
GO:0003945 (N-acetyllactosamine synthase activity)
GO:0004461 (lactose synthase activity)
GO:0008092 (cytoskeletal protein binding)
GO:0008378 (galactosyltransferase activity)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0019901 (protein kinase binding)
GO:0030145 (manganese ion binding)
GO:0035250 (UDP-galactosyltransferase activity)
GO:0042803 (protein homodimerization activity)
GO:0043014 (alpha-tubulin binding)
GO:0046872 (metal ion binding)
GO:0048487 (beta-tubulin binding)
GO Biological Process GO:0002064 (epithelial cell development)
GO:0002526 (acute inflammatory response)
GO:0005975 (carbohydrate metabolic process)
GO:0005989 (lactose biosynthetic process)
GO:0006012 (galactose metabolic process)
GO:0006486 (protein glycosylation)
GO:0006487 (protein N-linked glycosylation)
GO:0007155 (cell adhesion)
GO:0007339 (binding of sperm to zona pellucida)
GO:0007341 (penetration of zona pellucida)
GO:0008285 (negative regulation of cell proliferation)
GO:0009101 (glycoprotein biosynthetic process)
GO:0009312 (oligosaccharide biosynthetic process)
GO:0009611 (response to wounding)
GO:0018146 (keratan sulfate biosynthetic process)
GO:0030198 (extracellular matrix organization)
GO:0030879 (mammary gland development)
GO:0042060 (wound healing)
GO:0042127 (regulation of cell proliferation)
GO:0043065 (positive regulation of apoptotic process)
GO:0045136 (development of secondary sexual characteristics)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0050900 (leukocyte migration)
GO:0051270 (regulation of cellular component movement)
GO:0060046 (regulation of acrosome reaction)
GO:0060054 (positive regulation of epithelial cell proliferation involved in wound healing)
GO:0060055 (angiogenesis involved in wound healing)
GO:0060058 (positive regulation of apoptotic process involved in mammary gland involution)
Wikipedia B4GALT1

Target Cross References - Protein

canSAR P15291
CGD Congenital disorder of glycosylation, type IId
Human Protein Atlas ENSG00000086062
IntAct P15291
Open Targets ENSG00000086062
PharmGKB PA25223
Reactome R-HSA-1300644 (Interaction With The Zona Pellucida.)
R-HSA-1912420 (Pre-NOTCH Processing in Golgi.)
R-HSA-2022854 (Keratan sulfate biosynthesis.)
R-HSA-5653890 (Lactose synthesis.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-975577 (N-Glycan antennae elongation.)
UniProt B2R710 D3DRL2 P15291 Q12909 Q12910 Q12911 Q14456 Q14509 Q14523

Target Cross References - Domain

InterPro IPR003859 (Galactosyl_T.)
IPR027791 (Galactosyl_T_C.)
IPR027995 (Galactosyl_T_N.)
IPR029044 (Nucleotide-diphossugar_trans.)
Pfam PF02709 (Glyco_transf_7C)
PF13733 (Glyco_transf_7N)

Target Cross References - Structure

PDBe 2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41
CREDO 2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41
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