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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4379
Target Type SINGLE PROTEIN
Preferred Name ADAM17
Synonyms ADAM 17 | Adam17 | CD_antigen=CD156b | Disintegrin and metalloproteinase domain-containing protein 17 | TNF-alpha convertase | TNF-alpha-converting enzyme | Tace
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
Disintegrin and metalloproteinase domain-containing protein 17 SINGLE PROTEIN Q9Z0F8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0015629 (actin cytoskeleton)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0032587 (ruffle membrane)
GO:0045121 (membrane raft)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005112 (Notch binding)
GO:0005138 (interleukin-6 receptor binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0017124 (SH3 domain binding)
GO:0030165 (PDZ domain binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002467 (germinal center formation)
GO:0002532 (production of molecular mediator involved in inflammatory response)
GO:0006508 (proteolysis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0007155 (cell adhesion)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0008284 (positive regulation of cell proliferation)
GO:0010820 (positive regulation of T cell chemotaxis)
GO:0030183 (B cell differentiation)
GO:0030307 (positive regulation of cell growth)
GO:0030335 (positive regulation of cell migration)
GO:0030511 (positive regulation of transforming growth factor beta receptor signaling pathway)
GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway)
GO:0031659 (positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle)
GO:0032496 (response to lipopolysaccharide)
GO:0032722 (positive regulation of chemokine production)
GO:0033025 (regulation of mast cell apoptotic process)
GO:0033077 (T cell differentiation in thymus)
GO:0033627 (cell adhesion mediated by integrin)
GO:0035625 (epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway)
GO:0042493 (response to drug)
GO:0045741 (positive regulation of epidermal growth factor-activated receptor activity)
GO:0048536 (spleen development)
GO:0048870 (cell motility)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0051088 (PMA-inducible membrane protein ectodomain proteolysis)
GO:0051272 (positive regulation of cellular component movement)
GO:0055099 (response to high density lipoprotein particle)
GO:0060397 (JAK-STAT cascade involved in growth hormone signaling pathway)

Target Cross References - Protein

IntAct Q9Z0F8
Reactome R-MMU-177929 (Signaling by EGFR.)
R-MMU-193692 (Regulated proteolysis of p75NTR.)
R-MMU-75893 (TNF signaling.)
R-MMU-982772 (Growth hormone receptor signaling.)
UniProt O88726 Q505A7 Q9R1U4 Q9Z0F8 Q9Z0K3

Target Cross References - Domain

InterPro IPR001590 (Peptidase_M12B.)
IPR001762 (Disintegrin_dom.)
IPR002870 (Peptidase_M12B_N.)
IPR024079 (MetalloPept_cat_dom.)
IPR032029 (ADAM17_MPD.)
IPR034025 (ADAM10_ADAM17.)
Pfam PF00200 (Disintegrin)
PF01562 (Pep_M12B_propep)
PF16698 (ADAM17_MPD)
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