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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4374
Target Type SINGLE PROTEIN
Preferred Name Photoreceptor-specific nuclear receptor
Synonyms NR2E3 | Nuclear receptor subfamily 2 group E member 3 | PNR | Photoreceptor-specific nuclear receptor | RNR | Retina-specific nuclear receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group e > nuclear hormone receptor subfamily 2 group e member 3

Target Components

Component Description Relationship Accession
Photoreceptor-specific nuclear receptor SINGLE PROTEIN Q9Y5X4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000278570
Ensembl ENSG00000278570
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0007601 (visual perception)
GO:0007602 (phototransduction)
GO:0008285 (negative regulation of cell proliferation)
GO:0030522 (intracellular receptor signaling pathway)
GO:0042462 (eye photoreceptor cell development)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045872 (positive regulation of rhodopsin gene expression)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050896 (response to stimulus)
GO:0060041 (retina development in camera-type eye)
Wikipedia Photoreceptor_cell-specific_nuclear_receptor

Target Cross References - Protein

canSAR Q9Y5X4
CGD Enhanced S-cone syndrome; Retinitis pigmentosa 37
Human Protein Atlas ENSG00000278570
IntAct Q9Y5X4
Open Targets ENSG00000278570
PharmGKB PA31757
Pharos Q9Y5X4 (Tbio)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt B6ZGU0 Q9UHM4 Q9Y5X4

Target Cross References - Domain

InterPro IPR000003 (Retinoid-X_rcpt/HNF4.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 4LOG
CREDO 4LOG
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