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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4372
Target Type SINGLE PROTEIN
Preferred Name Anthrax lethal factor
Synonyms Anthrax lethal toxin endopeptidase component | Lethal factor | lef
Organism Bacillus anthracis
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m34 family

Target Components

Component Description Relationship Accession
Lethal factor SINGLE PROTEIN P15917

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301396 Antrax lethal toxin PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0090729 (toxin activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0006508 (proteolysis)
GO:0009405 (pathogenesis)
GO:0010629 (negative regulation of gene expression)
GO:0035897 (proteolysis in other organism)
GO:0043409 (negative regulation of MAPK cascade)
GO:0044533 (positive regulation of apoptotic process in other organism)
GO:0061136 (regulation of proteasomal protein catabolic process)
GO:0097300 (programmed necrotic cell death)
GO:1903140 (regulation of establishment of endothelial barrier)

Target Cross References - Protein

canSAR P15917
IntAct P15917
Reactome R-HSA-5210891 (Uptake and function of anthrax toxins.)
UniProt P15917 Q8KYJ6 Q933F6

Target Cross References - Domain

InterPro IPR003541 (Anthrax_toxin_lethal/edema.)
IPR014781 (Anthrax_toxin_lethal/edema_N/C.)
IPR015239 (Anthrax_LF_cen.)
IPR024079 (MetalloPept_cat_dom_sf.)
Pfam PF07737 (ATLF)
PF09156 (Anthrax-tox_M)

Target Cross References - Structure

PDBe 1J7N 1JKY 1PWP 1PWQ 1PWU 1PWV 1PWW 1YQY 1ZXV 3KWV 4DV8 4PKQ 4PKR 4PKS 4PKT 4PKU 4PKV 4PKW 4WF6 4XM6 4XM7 4XM8 5D1S 5D1T More...
CREDO 1J7N 1JKY 1PWP 1PWQ 1PWU 1PWV 1PWW 1YQY 1ZXV 3KWV 4DV8 4PKQ 4PKR 4PKS 4PKT 4PKU 4PKV 4PKW 4WF6 4XM6 4XM7 4XM8 5D1S 5D1T More...
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