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Target Report Card

Target Name and Classification

Target ID CHEMBL4360
Preferred Name Monocarboxylate transporter 1
Synonyms MCT 1 | MCT1 | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc16 family of monocarboxylate transporters

Target Components

Component Description Relationship Accession
Monocarboxylate transporter 1 SINGLE PROTEIN P53985

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000155380 ENSG00000281917
Ensembl ENSG00000155380 ENSG00000281917
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005813 (centrosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0008028 (monocarboxylic acid transmembrane transporter activity)
GO:0015129 (lactate transmembrane transporter activity)
GO:0015130 (mevalonate transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0042803 (protein homodimerization activity)
GO:0097159 (organic cyclic compound binding)
GO Biological Process GO:0006090 (pyruvate metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006810 (transport)
GO:0015718 (monocarboxylic acid transport)
GO:0015728 (mevalonate transport)
GO:0032094 (response to food)
GO:0035873 (lactate transmembrane transport)
GO:0035879 (plasma membrane lactate transport)
GO:0042593 (glucose homeostasis)
GO:0050796 (regulation of insulin secretion)
GO:0050900 (leukocyte migration)
GO:0051297 (centrosome organization)
GO:0051780 (behavioral response to nutrient)
GO:0055085 (transmembrane transport)
GO:0071407 (cellular response to organic cyclic compound)
Wikipedia SLC16A1

Target Cross References - Protein

CGD Hyperinsulinemic hypoglycemia, familial, 7; Erythrocyte lactate transporter defect
Human Protein Atlas ENSG00000155380 ENSG00000281917
IntAct P53985
Guide to Pharmacology 988
Open Targets ENSG00000155380 ENSG00000281917
PharmGKB PA35813
Reactome R-HSA-210991 (Basigin interactions.)
R-HSA-433692 (Proton-coupled monocarboxylate transport.)
R-HSA-70268 (Pyruvate metabolism.)
UniProt P53985 Q49A45 Q5T8R6 Q9NSJ9

Target Cross References - Domain

InterPro IPR004743 (MCT.)
IPR011701 (MFS.)
IPR020846 (MFS_dom.)
IPR030757 (MCT1.)
Pfam PF07690 (MFS_1)