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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4349
Target Type SINGLE PROTEIN
Preferred Name N-acylsphingosine-amidohydrolase
Synonyms ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | NAAA | PLT
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
N-acylethanolamine-hydrolyzing acid amidase SINGLE PROTEIN Q02083

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138744
Ensembl ENSG00000138744
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0043202 (lysosomal lumen)
GO:0045202 (synapse)
GO:0070062 (extracellular exosome)
GO:0098793 (presynapse)
GO Molecular Function GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0007269 (neurotransmitter secretion)
GO:0008150 (biological_process)
Wikipedia ASAHL

Target Cross References - Protein

canSAR Q02083
Human Protein Atlas ENSG00000138744
Guide to Pharmacology 1402
Open Targets ENSG00000138744
PharmGKB PA162396672
Reactome R-HSA-112310 (Neurotransmitter release cycle.)
UniProt Q02083 Q5KTF2 Q96EY2 Q9BRA8

Target Cross References - Domain

InterPro IPR016699 (Acid_ceramidase-like.)
IPR029130 (Acid_ceramidase_N.)
IPR029132 (CBAH/NAAA_C.)
Pfam PF02275 (CBAH)
PF15508 (NAAA-beta)
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