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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4328
Target Type SINGLE PROTEIN
Preferred Name Betaine--homocysteine S-methyltransferase 1
Synonyms BHMT | Betaine--homocysteine S-methyltransferase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Betaine--homocysteine S-methyltransferase 1 SINGLE PROTEIN Q93088

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3391661 Betaine-homocysteine S-methyltransferase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145692
Ensembl ENSG00000145692
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0008168 (methyltransferase activity)
GO:0008270 (zinc ion binding)
GO:0008898 (S-adenosylmethionine-homocysteine S-methyltransferase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO:0047150 (betaine-homocysteine S-methyltransferase activity)
GO Biological Process GO:0000096 (sulfur amino acid metabolic process)
GO:0006479 (protein methylation)
GO:0006577 (amino-acid betaine metabolic process)
GO:0006579 (amino-acid betaine catabolic process)
GO:0009086 (methionine biosynthetic process)
GO:0032259 (methylation)
GO:0042426 (choline catabolic process)
GO:0046500 (S-adenosylmethionine metabolic process)
GO:0050666 (regulation of homocysteine metabolic process)
GO:0071267 (L-methionine salvage)

Target Cross References - Protein

canSAR Q93088
Human Protein Atlas ENSG00000145692
IntAct Q93088
Open Targets ENSG00000145692
PharmGKB PA25350
Reactome R-HSA-1614635 (Sulfur amino acid metabolism.)
R-HSA-6798163 (Choline catabolism.)
UniProt Q93088 Q9UNI9

Target Cross References - Domain

InterPro IPR003726 (HCY_dom.)
IPR017226 (Betaine-hCys_S-MeTrfase_BHMT.)
Pfam PF02574 (S-methyl_trans)

Target Cross References - Structure

PDBe 1LT7 1LT8 4M3P
CREDO 1LT7 1LT8 4M3P
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