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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4308
Target Type SINGLE PROTEIN
Preferred Name Bradykinin B1 receptor
Synonyms B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BRADYB1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > bradykinin receptor

Target Components

Component Description Relationship Accession
B1 bradykinin receptor SINGLE PROTEIN P46663

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL232943 MK0686 Bradykinin B1 receptor antagonist 2 PubMed PubMed
CHEMBL1254771 Safotibant Bradykinin B1 receptor antagonist 2 Other PubMed
CHEMBL3545386 BI113823 Bradykinin B1 receptor antagonist 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100739
Ensembl ENSG00000100739
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004947 (bradykinin receptor activity)
GO:0005515 (protein binding)
GO:0042277 (peptide binding)
GO Biological Process GO:0001933 (negative regulation of protein phosphorylation)
GO:0002687 (positive regulation of leukocyte migration)
GO:0006950 (response to stress)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0009612 (response to mechanical stimulus)
GO:0016477 (cell migration)
GO:0019233 (sensory perception of pain)
GO:0030308 (negative regulation of cell growth)
GO:0032496 (response to lipopolysaccharide)
GO:0045776 (negative regulation of blood pressure)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
Wikipedia Bradykinin_receptor_B1

Target Cross References - Protein

canSAR P46663
Human Protein Atlas ENSG00000100739
IntAct P46663
Guide to Pharmacology 41
Open Targets ENSG00000100739
PharmGKB PA79
Pharos P46663 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt A8K7F5 P46663 Q546S7 Q8N0Y8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000496 (Brdyknn_rcpt.)
IPR001186 (Brdyknn_1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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