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Target Report Card

Target Name and Classification

Target ID CHEMBL4306
Preferred Name Voltage-gated potassium channel subunit Kv1.5
Synonyms HPCN1 | KCNA5 | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel HK2 | Voltage-gated potassium channel subunit Kv1.5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > voltage-gated potassium channel

Target Components

Component Description Relationship Accession
Potassium voltage-gated channel subfamily A member 5 SINGLE PROTEIN P22460

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2362996 Voltage-gated potassium channel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130037
Ensembl ENSG00000130037
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0008076 (voltage-gated potassium channel complex)
GO:0009986 (cell surface)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030018 (Z disc)
GO:0034705 (potassium channel complex)
GO:0045121 (membrane raft)
GO:0046691 (intracellular canaliculus)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005249 (voltage-gated potassium channel activity)
GO:0005251 (delayed rectifier potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0005515 (protein binding)
GO:0015271 (outward rectifier potassium channel activity)
GO:0019870 (potassium channel inhibitor activity)
GO:0019901 (protein kinase binding)
GO:0051393 (alpha-actinin binding)
GO:0086087 (voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization)
GO:0086089 (voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization)
GO:0086090 (voltage-gated potassium channel activity involved in SA node cell action potential repolarization)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0007219 (Notch signaling pathway)
GO:0009612 (response to mechanical stimulus)
GO:0010033 (response to organic substance)
GO:0019229 (regulation of vasoconstriction)
GO:0034765 (regulation of ion transmembrane transport)
GO:0042391 (regulation of membrane potential)
GO:0042542 (response to hydrogen peroxide)
GO:0043266 (regulation of potassium ion transport)
GO:0043267 (negative regulation of potassium ion transport)
GO:0050796 (regulation of insulin secretion)
GO:0051259 (protein oligomerization)
GO:0051260 (protein homooligomerization)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0055075 (potassium ion homeostasis)
GO:0055085 (transmembrane transport)
GO:0055093 (response to hyperoxia)
GO:0060081 (membrane hyperpolarization)
GO:0060372 (regulation of atrial cardiac muscle cell membrane repolarization)
GO:0071435 (potassium ion export)
GO:0071805 (potassium ion transmembrane transport)
GO:0086014 (atrial cardiac muscle cell action potential)
GO:0086050 (membrane repolarization during bundle of His cell action potential)
GO:0086052 (membrane repolarization during SA node cell action potential)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:0098914 (membrane repolarization during atrial cardiac muscle cell action potential)
GO:1900087 (positive regulation of G1/S transition of mitotic cell cycle)
GO:2000288 (positive regulation of myoblast proliferation)
Wikipedia KCNA5

Target Cross References - Protein

canSAR P22460
CGD Atrial fibrillation, familial, 7
Human Protein Atlas ENSG00000130037
IntAct P22460
Guide to Pharmacology 542
Open Targets ENSG00000130037
PharmGKB PA208
Pharos P22460 (Tclin)
Reactome R-HSA-1296072 (Voltage gated Potassium channels.)
UniProt P22460 Q4KKT8 Q4VAJ1 Q4VAJ2 Q9UDA4

Target Cross References - Domain

InterPro IPR000210 (BTB/POZ_dom.)
IPR003131 (T1-type_BTB.)
IPR003968 (K_chnl_volt-dep_Kv.)
IPR003972 (K_chnl_volt-dep_Kv1.)
IPR004052 (K_chnl_volt-dep_Kv1.5.)
IPR005821 (Ion_trans_dom.)
IPR011333 (SKP1/BTB/POZ_sf.)
IPR027359 (Volt_channel_dom_sf.)
IPR028325 (VG_K_chnl.)
Pfam PF00520 (Ion_trans)
PF02214 (BTB_2)