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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4297
Target Type SINGLE PROTEIN
Preferred Name Serotonin 1d (5-HT1d) receptor
Synonyms 5-HT-1D | 5-HT1D | 5-hydroxytryptamine receptor 1D | Gpcr14 | Htr1d | Serotonin receptor 1D
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 1D SINGLE PROTEIN Q61224

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0051378 (serotonin binding)
GO Biological Process GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0009636 (response to toxic substance)
GO:0014827 (intestine smooth muscle contraction)
GO:0040012 (regulation of locomotion)
GO:0042310 (vasoconstriction)
GO:0050795 (regulation of behavior)

Target Cross References - Protein

Reactome R-MMU-390666 (Serotonin receptors.)
R-MMU-418594 (G alpha (i) signalling events.)
UniProt Q3ZB48 Q61224 Q61615 Q8BUW7

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000505 (5HT1D_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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