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Target Report Card

Target Name and Classification

Target ID CHEMBL4273
Target Type SINGLE PROTEIN
Preferred Name cGMP-dependent protein kinase 1 beta
Synonyms PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | cGK 1 | cGK1 | cGKI | cGMP-dependent protein kinase 1 | cGMP-dependent protein kinase I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkg family

Target Components

Component Description Relationship Accession
cGMP-dependent protein kinase 1 SINGLE PROTEIN Q13976

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000185532
Ensembl ENSG00000185532
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004692 (cGMP-dependent protein kinase activity)
GO:0005246 (calcium channel regulator activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030553 (cGMP binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0001764 (neuron migration)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0008152 (metabolic process)
GO:0016310 (phosphorylation)
GO:0016358 (dendrite development)
GO:0019934 (cGMP-mediated signaling)
GO:0030036 (actin cytoskeleton organization)
GO:0030900 (forebrain development)
GO:0043087 (regulation of GTPase activity)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0060087 (relaxation of vascular smooth muscle)
GO:0090331 (negative regulation of platelet aggregation)
GO:1904706 (negative regulation of vascular smooth muscle cell proliferation)
GO:1904753 (negative regulation of vascular associated smooth muscle cell migration)
Wikipedia PRKG1

Target Cross References - Protein

canSAR Q13976
Human Protein Atlas ENSG00000185532
IntAct Q13976
Guide to Pharmacology 1492
Open Targets ENSG00000185532
PharmGKB PA33777
Pharos Q13976 (Tchem)
Reactome R-HSA-392517 (Rap1 signalling.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-418457 (cGMP effects.)
UniProt A5YM56 B3KSF3 E2PU10 P14619 Q13976 Q5JP05 Q5JSJ6 Q6P5T7

Target Cross References - Domain

InterPro IPR000595 (cNMP-bd_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002374 (cGMP_dep_kinase.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR014710 (RmlC-like_jellyroll.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR018488 (cNMP-bd_CS.)
IPR018490 (cNMP-bd-like.)
IPR031831 (PKcGMP_CC.)
IPR035014 (STKc_cGK.)
Pfam PF00027 (cNMP_binding)
PF00069 (Pkinase)
PF16808 (PKcGMP_CC)

Target Cross References - Structure

PDBe 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N
CREDO 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N
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