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Target Report Card

Target Name and Classification

Target ID CHEMBL4267
Preferred Name TGF-beta receptor type II
Synonyms TGF-beta receptor type II | TGF-beta receptor type-2 | TGF-beta type II receptor | TGFBR2 | TGFR-2 | TbetaR-II | Transforming growth factor-beta receptor type II
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 2 subfamily

Target Components

Component Description Relationship Accession
TGF-beta receptor type-2 SINGLE PROTEIN P37173

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163513
Ensembl ENSG00000163513
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO:0045121 (membrane raft)
GO:0070022 (transforming growth factor beta receptor homodimeric complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005024 (transforming growth factor beta-activated receptor activity)
GO:0005026 (transforming growth factor beta receptor activity, type II)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005539 (glycosaminoglycan binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031435 (mitogen-activated protein kinase kinase kinase binding)
GO:0034713 (type I transforming growth factor beta receptor binding)
GO:0034714 (type III transforming growth factor beta receptor binding)
GO:0038023 (signaling receptor activity)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0050431 (transforming growth factor beta binding)
GO Biological Process GO:0001568 (blood vessel development)
GO:0001569 (patterning of blood vessels)
GO:0001570 (vasculogenesis)
GO:0001666 (response to hypoxia)
GO:0001701 (in utero embryonic development)
GO:0001947 (heart looping)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0002088 (lens development in camera-type eye)
GO:0002651 (positive regulation of tolerance induction to self antigen)
GO:0002663 (positive regulation of B cell tolerance induction)
GO:0002666 (positive regulation of T cell tolerance induction)
GO:0003148 (outflow tract septum morphogenesis)
GO:0003149 (membranous septum morphogenesis)
GO:0003151 (outflow tract morphogenesis)
GO:0003181 (atrioventricular valve morphogenesis)
GO:0003186 (tricuspid valve morphogenesis)
GO:0003214 (cardiac left ventricle morphogenesis)
GO:0003274 (endocardial cushion fusion)
GO:0003417 (growth plate cartilage development)
GO:0003430 (growth plate cartilage chondrocyte growth)
GO:0006468 (protein phosphorylation)
GO:0006898 (receptor-mediated endocytosis)
GO:0006915 (apoptotic process)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007182 (common-partner SMAD protein phosphorylation)
GO:0007219 (Notch signaling pathway)
GO:0007224 (smoothened signaling pathway)
GO:0007369 (gastrulation)
GO:0007420 (brain development)
GO:0007507 (heart development)
GO:0007566 (embryo implantation)
GO:0007568 (aging)
GO:0007584 (response to nutrient)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009612 (response to mechanical stimulus)
GO:0009749 (response to glucose)
GO:0009887 (organ morphogenesis)
GO:0010033 (response to organic substance)
GO:0010468 (regulation of gene expression)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0014070 (response to organic cyclic compound)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030154 (cell differentiation)
GO:0030324 (lung development)
GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway)
GO:0031100 (organ regeneration)
GO:0032147 (activation of protein kinase activity)
GO:0035162 (embryonic hemopoiesis)
GO:0040008 (regulation of growth)
GO:0042060 (wound healing)
GO:0042127 (regulation of cell proliferation)
GO:0042493 (response to drug)
GO:0043011 (myeloid dendritic cell differentiation)
GO:0043415 (positive regulation of skeletal muscle tissue regeneration)
GO:0043627 (response to estrogen)
GO:0045766 (positive regulation of angiogenesis)
GO:0048545 (response to steroid hormone)
GO:0048565 (digestive tract development)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0048701 (embryonic cranial skeleton morphogenesis)
GO:0051138 (positive regulation of NK T cell differentiation)
GO:0051216 (cartilage development)
GO:0060044 (negative regulation of cardiac muscle cell proliferation)
GO:0060389 (pathway-restricted SMAD protein phosphorylation)
GO:0060412 (ventricular septum morphogenesis)
GO:0060425 (lung morphogenesis)
GO:0060433 (bronchus development)
GO:0060434 (bronchus morphogenesis)
GO:0060439 (trachea morphogenesis)
GO:0060440 (trachea formation)
GO:0060443 (mammary gland morphogenesis)
GO:0060463 (lung lobe morphogenesis)
GO:0062009 (secondary palate development)
GO:0070723 (response to cholesterol)
GO:1905007 (positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)
GO:1905315 (cell proliferation involved in endocardial cushion morphogenesis)
GO:1905316 (superior endocardial cushion morphogenesis)
GO:1905317 (inferior endocardial cushion morphogenesis)
GO:1990086 (lens fiber cell apoptotic process)
GO:1990428 (miRNA transport)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2000563 (positive regulation of CD4-positive, alpha-beta T cell proliferation)
Wikipedia TGF_beta_receptor_2

Target Cross References - Protein

canSAR P37173
CGD Loeys-Dietz syndrome, type 2B; Loeys-Dietz syndrome, type 1B
Human Protein Atlas ENSG00000163513
IntAct P37173
Guide to Pharmacology 1795
Open Targets ENSG00000163513
PharmGKB PA36486
Pharos P37173 (Tchem)
Reactome R-HSA-2173788 (Downregulation of TGF-beta receptor signaling.)
R-HSA-2173789 (TGF-beta receptor signaling activates SMADs.)
R-HSA-2173791 (TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).)
R-HSA-3304356 (SMAD2/3 Phosphorylation Motif Mutants in Cancer.)
R-HSA-3315487 (SMAD2/3 MH2 Domain Mutants in Cancer.)
R-HSA-3642279 (TGFBR2 MSI Frameshift Mutants in Cancer.)
R-HSA-3645790 (TGFBR2 Kinase Domain Mutants in Cancer.)
R-HSA-3656532 (TGFBR1 KD Mutants in Cancer.)
R-HSA-3656535 (TGFBR1 LBD Mutants in Cancer.)
R-HSA-5689603 (UCH proteinases.)
UniProt B4DTV5 P37173 Q15580 Q6DKT6 Q99474

Target Cross References - Domain

InterPro IPR000333 (TGFB_receptor.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR015013 (Transforming_GF_b_rcpt_2_ecto.)
IPR017194 (Transform_growth_fac-b_typ-2.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF07714 (Pkinase_Tyr)
PF08917 (ecTbetaR2)

Target Cross References - Structure

PDBe 1KTZ 1M9Z 2PJY 3KFD 4P7U 4XJJ 5E8V 5E8Y 5E91 5E92 5TX4
CREDO 1KTZ 1M9Z 2PJY 3KFD 4P7U 4XJJ 5E8V 5E8Y 5E91 5E92 5TX4