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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4247
Target Type SINGLE PROTEIN
Preferred Name ALK tyrosine kinase receptor
Synonyms ALK tyrosine kinase receptor | ALK | Anaplastic lymphoma kinase | CD_antigen=CD246
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 1 subfamily

Target Components

Component Description Relationship Accession
ALK tyrosine kinase receptor SINGLE PROTEIN Q9UM73

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111387 NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL601719 CRIZOTINIB ALK tyrosine kinase receptor inhibitor 4 FDA
CHEMBL2403108 CERITINIB ALK tyrosine kinase receptor inhibitor 4 FDA
CHEMBL3707320 ALECTINIB HYDROCHLORIDE ALK tyrosine kinase receptor inhibitor 4 FDA
CHEMBL3545311 BRIGATINIB ALK tyrosine kinase receptor inhibitor 3 Other Other PubMed
CHEMBL3544934 X-396 ALK tyrosine kinase receptor inhibitor 1 Other PubMed
CHEMBL3545051 CEP-37440 ALK tyrosine kinase receptor inhibitor 1 DOI PubMed PubMed
CHEMBL3545360 ASP-3026 ALK tyrosine kinase receptor inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171094
Ensembl ENSG00000171094
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043234 (protein complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004704 (NF-kappaB-inducing kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007399 (nervous system development)
GO:0008283 (cell proliferation)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0038061 (NIK/NF-kappaB signaling)
GO:0042981 (regulation of apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:0048666 (neuron development)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
Wikipedia Anaplastic_lymphoma_kinase

Target Cross References - Protein

canSAR Q9UM73
CGD Neuroblastoma, susceptibility to, 3
Human Protein Atlas ENSG00000171094
IntAct Q9UM73
Guide to Pharmacology 1839
Open Targets ENSG00000171094
PharmGKB PA24719
Pharos Q9UM73 (Tclin)
UniProt Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9UM73 Q9Y4K6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000998 (MAM_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR002172 (LDrepeatLR_classA_rpt.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013320 (ConA-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR026830 (ALK.)
Pfam PF00629 (MAM)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB More...
CREDO 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB More...
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