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Target Report Card

Target Name and Classification

Target ID CHEMBL4246
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase TEC
Synonyms PSCTK4 | TEC | Tyrosine-protein kinase Tec
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase tec family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Tec SINGLE PROTEIN P42680

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135605
Ensembl ENSG00000135605
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005543 (phospholipid binding)
GO:0008289 (lipid binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007229 (integrin-mediated signaling pathway)
GO:0010543 (regulation of platelet activation)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030154 (cell differentiation)
GO:0035556 (intracellular signal transduction)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042246 (tissue regeneration)
GO:0045087 (innate immune response)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050853 (B cell receptor signaling pathway)
Wikipedia TEC_(gene)

Target Cross References - Protein

canSAR P42680
Human Protein Atlas ENSG00000135605
IntAct P42680
Guide to Pharmacology 2238
Open Targets ENSG00000135605
PharmGKB PA36436
Pharos P42680 (Tchem)
Reactome R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
R-HSA-512988 (Interleukin-3, 5 and GM-CSF signaling.)
UniProt B7ZKZ6 P42680 Q3MIS5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR001562 (Znf_Btk_motif.)
IPR001849 (PH_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011993 (PH-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR035572 (Tec_SH3.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF00169 (PH)
PF00779 (BTK)
PF07714 (Pkinase_Tyr)
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