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Target Report Card

Target Name and Classification

Target ID CHEMBL4234
Preferred Name Estradiol 17-beta-dehydrogenase 3
Synonyms 17-beta-HSD 3 | 17-beta-hydroxysteroid dehydrogenase type 3 | EDH17B3 | HSD17B3 | SDR12C2 | Short chain dehydrogenase/reductase family 12C member 2 | Testicular 17-beta-hydroxysteroid dehydrogenase | Testosterone 17-beta-dehydrogenase 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Testosterone 17-beta-dehydrogenase 3 SINGLE PROTEIN P37058

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130948
Ensembl ENSG00000130948
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0016491 (oxidoreductase activity)
GO:0047035 (testosterone dehydrogenase (NAD+) activity)
GO:0047045 (testosterone 17-beta-dehydrogenase (NADP+) activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006702 (androgen biosynthetic process)
GO:0030539 (male genitalia development)
GO:0055114 (oxidation-reduction process)
GO:0061370 (testosterone biosynthetic process)
Wikipedia HSD17B3_(gene)

Target Cross References - Protein

canSAR P37058
CGD 17-Beta hydroxysteroid dehydrogenase III deficiency
Human Protein Atlas ENSG00000130948
IntAct P37058
Open Targets ENSG00000130948
PharmGKB PA29480
Reactome R-HSA-193048 (Androgen biosynthesis.)
R-HSA-75876 (Synthesis of very long-chain fatty acyl-CoAs.)
UniProt P37058 Q5U0Q6

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR020904 (Sc_DH/Rdtase_CS.)
IPR033281 (HSD17B3.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF00106 (adh_short)