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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4226
Target Type SINGLE PROTEIN
Preferred Name Dual specificity protein kinase CLK3
Synonyms CDC-like kinase 3 | CLK3 | Dual specificity protein kinase CLK3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase clk family

Target Components

Component Description Relationship Accession
Dual specificity protein kinase CLK3 SINGLE PROTEIN P49761

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000179335
Ensembl ENSG00000179335
GO Cellular Component GO:0001669 (acrosomal vesicle)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0016020 (membrane)
GO:0016607 (nuclear speck)
GO:0031410 (cytoplasmic vesicle)
GO:0045111 (intermediate filament cytoskeleton)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003723 (RNA binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0043484 (regulation of RNA splicing)
GO:0046777 (protein autophosphorylation)
Wikipedia CLK3_(gene)

Target Cross References - Protein

canSAR P49761
Human Protein Atlas ENSG00000179335
IntAct P49761
Guide to Pharmacology 1992
Open Targets ENSG00000179335
PharmGKB PA26597
Pharos P49761 (Tbio)
UniProt D3DW59 P49761 Q53Y48 Q9BRS3 Q9BUJ7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2EU9 2EXE 2WU6 2WU7 3RAW
CREDO 2EU9 2EXE 2WU6 2WU7 3RAW
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