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Target Report Card

Target Name and Classification

Target ID CHEMBL4224
Preferred Name Dual specificty protein kinase CLK1
Synonyms CDC-like kinase 1 | CLK | CLK1 | Dual specificity protein kinase CLK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase clk family

Target Components

Component Description Relationship Accession
Dual specificity protein kinase CLK1 SINGLE PROTEIN P49759

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000013441
Ensembl ENSG00000013441
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0008283 (cell proliferation)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0043484 (regulation of RNA splicing)
GO:0046777 (protein autophosphorylation)
Wikipedia CLK1

Target Cross References - Protein

canSAR P49759
Human Protein Atlas ENSG00000013441
IntAct P49759
Guide to Pharmacology 1990
Open Targets ENSG00000013441
PharmGKB PA26594
Pharos P49759 (Tchem)
UniProt B4DFW7 P49759 Q0P694 Q8N5V8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1Z57 2VAG 5J1V 5J1W 5X8I
CREDO 1Z57 2VAG 5J1V 5J1W 5X8I