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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4223
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase FRK
Synonyms FRK | FYN-related kinase | Nuclear tyrosine protein kinase RAK | PTK5 | Protein-tyrosine kinase 5 | RAK | Tyrosine-protein kinase FRK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase FRK SINGLE PROTEIN P42685

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363074 SRC PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1946170 REGORAFENIB Tyrosine-protein kinase FRK inhibitor 4 Expert

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111816
Ensembl ENSG00000111816
GO Cellular Component GO:0005576 (extracellular region)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0035578 (azurophil granule lumen)
GO:0035580 (specific granule lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0008285 (negative regulation of cell proliferation)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0030154 (cell differentiation)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0043312 (neutrophil degranulation)
GO:0045087 (innate immune response)
Wikipedia Fyn-related_kinase

Target Cross References - Protein

canSAR P42685
Human Protein Atlas ENSG00000111816
IntAct P42685
Guide to Pharmacology 2025
Open Targets ENSG00000111816
PharmGKB PA28373
Pharos P42685 (Tchem)
Reactome R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-8948751 (Regulation of PTEN stability and activity.)
UniProt B4DY49 P42685 Q13128 Q9NTR5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR035805 (SH2_Frk.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
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