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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4205
Preferred Name Voltage-gated potassium channel subunit Kv1.4
Synonyms HPCN2 | KCNA4 | KCNA4L | Potassium voltage-gated channel subfamily A member 4 | Voltage-gated K(+) channel HuKII | Voltage-gated potassium channel HBK4 | Voltage-gated potassium channel HK1 | Voltage-gated potassium channel subunit Kv1.4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > voltage-gated potassium channel

Target Components

Component Description Relationship Accession
Potassium voltage-gated channel subfamily A member 4 SINGLE PROTEIN P22459

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2362996 Voltage-gated potassium channel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182255
Ensembl ENSG00000182255
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0042995 (cell projection)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005249 (voltage-gated potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0005515 (protein binding)
GO:0030955 (potassium ion binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0034765 (regulation of ion transmembrane transport)
GO:0051260 (protein homooligomerization)
GO:0055085 (transmembrane transport)
GO:0071805 (potassium ion transmembrane transport)
Wikipedia KCNA4

Target Cross References - Protein

Human Protein Atlas ENSG00000182255
IntAct P22459
Open Targets ENSG00000182255
PharmGKB PA207
Pharos P22459 (Tclin)
Reactome R-HSA-1296072 (Voltage gated Potassium channels.)
UniProt P22459

Target Cross References - Domain

InterPro IPR000210 (BTB/POZ_dom.)
IPR003131 (T1-type_BTB.)
IPR003968 (K_chnl_volt-dep_Kv.)
IPR003972 (K_chnl_volt-dep_Kv1.)
IPR005821 (Ion_trans_dom.)
IPR011333 (SKP1/BTB/POZ_sf.)
IPR012897 (K_chnl_volt-dep_Kv1.4_TID.)
IPR020467 (K_chnl_volt-dep_Kv1.4.)
IPR027359 (Volt_channel_dom_sf.)
IPR028325 (VG_K_chnl.)
IPR037065 (K_chnl_volt-dep_Kv1.4_TID_sf.)
Pfam PF00520 (Ion_trans)
PF02214 (BTB_2)
PF07941 (K_channel_TID)