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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4202
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase 2
Synonyms CTCL tumor antigen se20-9 | KIAA0204 | SLK | STE20-like kinase | STE20-like serine/threonine-protein kinase | STE20-related kinase | STE20-related serine/threonine-protein kinase | STK2 | Serine/threonine-protein kinase 2 | hSLK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste20 family > ste protein kinase slk subfamily

Target Components

Component Description Relationship Accession
STE20-like serine/threonine-protein kinase SINGLE PROTEIN Q9H2G2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065613
Ensembl ENSG00000065613
GO Cellular Component GO:0005737 (cytoplasm)
GO:0031252 (cell leading edge)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0045296 (cadherin binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007346 (regulation of mitotic cell cycle)
GO:0016310 (phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030334 (regulation of cell migration)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0031122 (cytoplasmic microtubule organization)
GO:0032147 (activation of protein kinase activity)
GO:0042981 (regulation of apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:0051893 (regulation of focal adhesion assembly)
Wikipedia SLK_(gene)

Target Cross References - Protein

canSAR Q9H2G2
Human Protein Atlas ENSG00000065613
IntAct Q9H2G2
Guide to Pharmacology 2200
Open Targets ENSG00000065613
PharmGKB PA35941
Pharos Q9H2G2 (Tchem)
UniProt D3DRA0 D3DRA1 O00211 Q6P1Z4 Q86WU7 Q86WW1 Q92603 Q9H2G2 Q9NQL0 Q9NQL1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001943 (UVR_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR022165 (PKK.)
Pfam PF00069 (Pkinase)
PF12474 (PKK)

Target Cross References - Structure

PDBe 2J51 2JFL 2JFM 2UV2 4USF
CREDO 2J51 2JFL 2JFM 2UV2 4USF
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